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Bioavailability enhancement
Development of orally disintegrating tablets containing solid dispersion of a poorly soluble drug…
Diacerein (DCN), a potent anti-inflammatory API used to treat osteoarthritis yet, it suffers from poor water solubility which affects its oral absorption. Unabsorbed colonic DCN is converted into rhein, which is responsible for laxation as a main side effect of DCN treatment. Therefore, in this…
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A clever combination: galenIQ™ enhances the taste and formulation properties of vitamin D…
A clever combination
galenIQ™ enhances the taste and formulation properties of vitamin D supplements
Winter is here and the days are short. This means a lack of direct sunlight and, in turn, depleting levels of vitamin D in the body. In addition, owing to the coronavirus pandemic and recent…
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Advances in lipid carriers for drug delivery to the gastrointestinal tract
Lipid-based formulations have reemerged as oral drug delivery systems. Advances in the techniques to evaluate the in vivo fate of the formulations, together with an improved knowledge of the gastrointestinal-related processes/barriers to the evolving lipid-based systems, could explain, at least…
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Exploring precipitation inhibitors to improve in vivo absorption of cinnarizine from supersaturated…
Supersaturated lipid-based drug delivery systems are increasingly being explored as a bio-enabling formulation approach, particularly in preclinical evaluation of poorly-water soluble drugs. While increasing the drug load through thermally-induced supersaturation resulted in enhanced in vivo…
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A novel amorphous solid dispersion based on drug–polymer complexation
Rafoxanide (RAF) is a poorly water-soluble drug that forms a complex with povidone K25 (PVP) in a cosolvent system containing acetone and an alkaline aqueous medium. This study aims to investigate the impact of RAF-PVP complexation on in vitro and in vivo release of RAF. We prepared two RAF…
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An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins in…
While each route of therapeutic drug delivery has its own advantages and limitations, oral delivery is often favored because it offers convenient painless administration, sustained delivery, prolonged shelf life, and often lower manufacturing cost. Its limitations include mucus and epithelial cell…
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Nose-to-brain delivery of drug nanocrystals by using Ca2+ responsive deacetylated gellan gum based…
The objective of this study is to use a carbohydrate polymer deacetylated gellan gum (DGG) as matrix to design nanocrystals based intranasal in situ gel (IG) for nose-to -brain delivery of drug. The harmine nanocrystals (HAR-NC) as model drug were prepared by coupling homogenization and spray-drying…
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Leveraging bile solubilization of poorly water-soluble drugs by rational polymer selection
Poorly water-soluble drugs frequently solubilize into bile colloids and this natural mechanism is key for efficient bioavailability. We tested the impact of pharmaceutical polymers on this solubilization interplay using proton nuclear magnetic resonance spectroscopy, dynamic light scattering, and by…
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Vicissitudes of liquid crystals for solubility enhancement of poorly soluble drugs
A drug product should have aqueous solubility to avoid bioavailability issues. Low and erratic bioavailability is a problem encountered by almost 40–60% of new drug products coming out of research and development which are aimed to be delivered orally. This issue hampers their safety and efficacy as…
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Lipid-based formulations: A winning strategy for oral bioavailability enhancement
The key to lipid-based formulation success relies in the right selection of the lipid excipients to develop an optimized formulation, enabling solubilization of the drug throughout the digestion process for enhancement of oral bioavailability.
If you are not familiar with lipid-based formulation,…
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