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Bioavailability enhancement
Impact of polymer type, ASD loading and polymer-drug ratio on ASD tablet disintegration and drug…
Amorphous solid dispersion (ASD) has become an attractive strategy to enhance solubility and bioavailability of poorly water-soluble drugs. To facilitate oral administration, ASDs are commonly incorporated into tablets. Disintegration and drug release from ASD tablets are thus critical for achieving…
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A novel amorphous solid dispersion based on drug–polymer complexation
Rafoxanide (RAF) is a poorly water-soluble drug that forms a complex with povidone K25 (PVP) in a cosolvent system containing acetone and an alkaline aqueous medium. This study aims to investigate the impact of RAF-PVP complexation on in vitro and in vivo release of RAF. We prepared two RAF…
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Effect of Carrier Type and Tween® 80 Concentration on the Silymarin Release from the Solid…
The following poster was presented first at AAPS PharmSci 360 in October 2020. We had the chance to get a short introduction from the creator Valentyn Mohylyuk as a audio file.
PURPOSE
Silybin (the active component of Silymarin) is a weak acid (pKa 5.7) having low solubility in gastric…
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Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines
Over the last few years, conventional medicine has been increasingly moving towards precision medicine. Today, the production of oral pharmaceutical forms tailored to patients is not achievable by traditional industrial means. A promising solution to customize oral drug delivery has been found in…
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Liquisolid tablets – A rationale for formulation and process design
A significant proportion of new API’s in development are poorly soluble and require alternative formulation approaches to achieve adequate oral bioavailability. One option is to develop lipid-based formulations. Lipid formulations are typically liquids but can be converted into solid dosage forms…
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Bioavailability Improvement of Carbamazepine via Oral Administration of Modified-Release Amorphous…
The purpose of this study was to improve the bioavailability of carbamazepine (CBZ), a poorly water-soluble antiepileptic drug, via modified-release amorphous solid dispersions (mr-ASD) by a thin film freezing (TFF) process. Three types of CBZ-mr-ASD with immediate-, delayed-, and controlled-release…
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SMEDDS And Liquisolid Compacts To Simultaneously Improve The Solubility And Processability of…
Hydrochlorothiazide (HCTZ) is a class IV BCS drug that exhibits varying bioavailability due to poor solubility and low permeability. The first part of the present investigation was aimed to prepare liquid self-microemulsifying drug delivery system (SMEDDS) of HCTZ to improve its dissolution…
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Design of a self-unfolding delivery concept for oral administration of macromolecules
Delivering macromolecular drugs, e.g. peptides, to the systemic circulation by oral administration is challenging due to their degradation in the gastrointestinal tract and low transmucosal permeation. In this study, the concept of an oral delivery device utilizing an elastomeric material is…
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Enhancement of solubility and dissolution rate of fenofibrate using β-Cyclodextrin
The aim of the present research work, fenofibrate a BCS class II antihyperlipidemic drug belongs to fibrate class was formulated as solid dispersions using various hydrophilic carriers to enhance the solubility, dissolution rate, and oral bioavailability.
Methodology: Various techniques such as…
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Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds
Phenolic compounds are one of the most widespread classes of compounds in nature, with several beneficial biological effects being associated with their anti-oxidant and anti-carcinogenic activities. Their application in the prevention or treatment of numerous chronic diseases have been studied, but…
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