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Bioavailability enhancement
Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal…
Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions in order to overcome the solubility barrier of BCS Class II substances. However, the application of mechanically and thermally intensive processes is not…
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Development of piroxicam mini-tablets enabled by spherical cocrystallization
We examined the potential of the spherical cocrystallization (SCC) technology in simultaneously enhancing tablet manufacturability and dissolution of poorly soluble drugs by developing a mini-tablet formulation of piroxicam. The manufacturing of mini-tablets using a direct compression (DC) process…
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Design, Fabrication & Characterization of Graft Co-Polymer Assisted Ocular Insert: A State of…
Targeted delivery of drugs at appropriate concentrations to ocular tissues is required to avoid wastage. Hence, advanced systems that maximize the release of poorly soluble drugs and deliver them at ocular sites must be designed.
Methods: In this study, Soluplus® (polyvinyl caprolactam–polyvinyl…
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Supersaturable self-microemulsifying drug delivery system enhances dissolution and bioavailability…
To enhance the dissolution and oral bioavailability of telmisartan (TMS), a poorly water-soluble anti-hypertensive drug, a supersaturable self-microemulsifying drug delivery system (SuSMEDDS) was developed. Amorphous alkalinized TMS (AAT) was formulated into a SMEDDS, composed of Capmul® MCM (oil),…
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Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison…
Amorphous formulation technologies to improve oral absorption of poorly soluble active pharmaceutical ingredients (APIs) have become increasingly prevalent. Currently, polymer-based amorphous formulations manufactured by spray drying, hot melt extrusion (HME), or co-precipitation are most common.…
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Influence of shellac on the improvement of solubility and supersaturation of loratadine amorphous…
The use of ternary amorphous solid dispersions (ASDs) comprised of surfactants and synthetic polymers to improve the solubility of low water soluble active pharmaceutical ingredients (APIs) have been widely investigated as an emerging concept. Shellac is used as complex resin for coating purposes,…
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Fabrication and evaluation of fast disintegrating pellets of cilostazol
The present study was designed to formulate and develop fast disintegrating pellets of poorly soluble model drug (cilostazol) by reducing the proportion of micro-crystalline cellulose with pre-gelatinized starch (PGS), lactose and chitosan. The bioavailability enhancement of a model drug was…
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Developing and scaling up fast-dissolving electrospun formulations based on poly(vinylpyrrolidone)…
Poly(vinyl pyrrolidone) (PVP) electrospun fibers loaded with ketoprofen were fabricated in this work as potential fast dissolving drug delivery systems (DDSs) for oral delivery. By changing the processing parameters and collector geometry it was possible to increase the throughput rate from 1 to 20…
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Enhancement of Curcumin Solubility Using a Novel Solubilizing Polymer Soluplus®
In this study, a novel solubility enhancement excipient (Soluplus®) was investigated to improve the solubility and dissolution rate of Curcumin, a poorly water soluble drug.
Methods
Various methods were utilized for the fabrication of Curcumin-Soluplus® mixtures, including the physical mixture,…
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Formulation design and pharmacokinetic evaluation of docosahexaenoic acid containing…
Docosahexaenoic acid is a omega-3-fatty acid which together with other long-chain omega-3-fatty acid known to have protective effect against various diseases including hypertension, myocardial infarction, Alzheimer disease, and cancers. Poor bioavailability owning to limited aqueous solubility…
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