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Bioavailability enhancement
Solid self-emulsifying casein carrier for the improvement on the oral bioavailability of simvastatin
Simvastatin (SV) is a statin drug that can effectively control cholesterol and prevent cardiovascular diseases. However, SV is water-insoluble, and poor oral bioavailability (<5 %). Solid self-emulsifying carrier system is more stable than liquid emulsions, facilitating to improve the solubility…
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Advances in Nanocarrier Systems for Overcoming Formulation Challenges of Curcumin: Current Insights
Abstract
Curcumin, an organic phenolic molecule that is extracted from the rhizomes of Curcuma longa Linn, has undergone extensive evaluation for its diverse biological activities in both animals and humans. Despite its favorable characteristics, curcumin encounters various formulation challenges…
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Improving Active Pharmaceutical Ingredient Formulation by Hot Melt Extrusion
This poster was presented at PBP World Meeting 2024 in Vienna:
The integration of Artificial Intelligence (AI) and big data into pharmaceutical research over the past two decades has revolutionized drug discovery, enabling the identification of therapeutic targets with high accuracy and…
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Based on Eudragit® encapsulated ionic polymer IR775@nido-carborane strategy: release, bioactivity…
To enhance the bioavailability of carborane as a potential pharmacophore for BNCT, we labeled the modified o-carborane with the near-infrared dye IR775 and encapsulated it using two types of Eudragit® (pH-sensitive and osmotic). Consequently, four separate fluorescent complexes containing carborane…
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Enhancing Drug Efficacy: Gattefossé’s Expertise in Excipient Selection
About our company
The Gattefossé Group is a community of employees, all driven by a dual mission: the performance of its products and the personalized support to its customers. Gattefossé develops, manufactures and sells cosmetic ingredients and pharmaceutical excipients of natural origin for…
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Self-microemulsifying drug delivery system as carrier for the oral delivery of glimepiride:…
Abstract
Aim: The research aimed to design the glimepiride self-micro emulsifying drug delivery system (SMEDDS) for increased oral bioavailability in albino mice by assessing hypoglycemic efficacy.
Materials and Methods: The optimized liquid SMEDDS (L-SMEDDS) prepared by emulsification of…
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Fabrication of β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin inclusion complexes of Palbociclib:…
Palbociclib (PAL) is an anti-cancer molecule that is highly selective for CDK4/6 inhibition and approved for the management of advanced breast cancer. Due to its down-and-out aqueous solubility and poor oral bioavailability, therapeutic applications have been compromised in the pharmaceutical field.…
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Unveiling the potential of microsponges: Enhancing oral bioavailability
Abstract
Oral medication administration is widely recognized as the most practical and widely used method. Medications with a short half-life and easy absorption in the gastrointestinal tract are quickly removed by the bloodstream. To avoid these issues, oral controlled-release formulations have…
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Vitamin E & TPGS Reimagined: ADM’s Novatol® and Decanox® Solutions
The sky’s the limit with ADM’s Novatol® naturally derived Decanox® mixed tocopherols and vitamin E. These powerful and plant-based antioxidants are the ideal way to help protect cells in the body from oxidative stress. Further, Novatol® vitamin E is twice as effective as synthetic vitamin E…
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Simplex Lattice Design and Machine Learning Methods for the Optimization of Novel Microemulsion…
Novel p-coumaric acid microemulsion systems were developed to circumvent its absorption and bioavailability challenges. Simplex-lattice mixture design and machine learning methods were employed for optimization. Two optimized formulations were characterized using in vitro re-dispersibility and…
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