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Bioavailability enhancement
Enhanced oral bioavailability of self-Assembling curcumin-vitamin E prodrug-nanoparticles by…
Curcumin (CUR), a non-toxic natural compound with potent antitumor activity, was limited in clinical application due to its insolubility and exceedingly low bioavailability. In this study, a novel prodrug-nanoparticles (CSSV/TPGS-NPs) self-assembled by co-nanoprecipitation of curcumin-s-s-vitamin E…
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Preparation and Evaluation of Mebendazole Microemulsion for Intranasal Delivery: an Alternative…
Although mebendazole (MBZ) has demonstrated antitumor activity in glioblastoma models, the drug has low aqueous solubility and therefore is poorly absorbed. Considering that other strategies are needed to improve its bioavailability, the current study was aimed to develop and evaluate novel…
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Role of the Encapsulation in Bioavailability of Phenolic Compounds
Plant-derived phenolic compounds have multiple positive health effects for humans attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc. These effects strongly depend on their bioavailability in the organism. Bioaccessibility, and consequently bioavailability of…
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Microwave Induced Dielectric Heating for the On-demand Development of Indomethacin Amorphous Solid…
The poor aqueous solubility of drugs challenges their pharmaceutical development and oral bioavailability. At present, the development of dosage forms with poorly water-soluble drugs by means of amorphous solid dispersions (ASDs) approach has been an active area of research. Meanwhile, dielectric…
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Characterizing and Exploring the Differences in Dissolution and Stability Between Crystalline Solid…
Solid dispersion is one of the most effective ways to improve the dissolution of insoluble drugs. When the carrier can highly disperse the drug, it will increase the wettability of the drug and reduce the surface tension, thus improving the solubility, dissolution, and bioavailability. However,…
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Improving the dissolution of a water-insoluble orphan drug through a fused deposition modelling…
Lennox-Gastaut Syndrome (LGS) is a rare form of childhood epilepsy. Rufinamide is an orphan drug indicated for the treatment of LGS. Three-Dimensional Printing (3DP) is a process in which solid objects are created based on a digital file by adding materials layer by layer. Fused deposition modelling…
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Impact of drying on dissolution behavior of carvedilol-loaded sustained release solid dispersion:…
The present study aimed to develop carvedilol (CAR)-loaded (25% w/w) sustained release solid dispersion (SRSD), for enhanced dissolution and to explore the applicability of different industrially accessible drying techniques.
Methods
SRSD-CAR containing different ratios of polymers were prepared…
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Enhanced oral bioavailability of Bisdemethoxycurcumin-loaded self-microemulsifying drug delivery…
In this study, we sought to overcome the poor solubility and bioavailability of bismethoxycurcumin (BDMC) by fabricating a BDMC-loaded self micro-emulsifying system (BDMC-SMEDDS). Solubility and compatibility tests, pseudo-ternary phase diagrams (PTPDs) as well as d-optimal concept was applied to…
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Water-Induced Phase Separation of Spray-Dried Amorphous Solid Dispersions
Spray drying is widely used in the manufacturing of amorphous solid dispersion (ASD) systems due to its fast drying rate, enabling kinetic trapping of the drug in amorphous form. Spray-drying conditions, such as solvent composition, can have a profound impact on the properties of spray-dried…
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Development of Remdesivir as a Dry Powder for Inhalation by Thin Film Freezing
Remdesivir exhibits in vitro activity against SARS-CoV-2 and was granted approval for Emergency Use. To maximize delivery to the lungs, we formulated remdesivir as a dry powder for inhalation using thin film freezing (TFF). TFF produces brittle matrix nanostructured aggregates that are sheared into…
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