Browsing Category
Bioavailability enhancement
The effects of spray drying, HPMCAS grade, and compression speed on the compaction properties of…
Spray dried dispersions (SDDs) have the potential to dramatically improve the oral bioavailability of drugs with poor water solubility. However, SDDs tend to have material attributes, such as small particle size, low bulk density, and poor flowability, which are undesirable for downstream processing…
Read More...
Read More...
Overcoming the dissolution rate, gastrointestinal permeability and oral bioavailability of…
Simvastatin (SIM) and glimepiride (GLM) were co-formulated into nanosuspensions and self-nanoemulsifying drug delivery systems (SNEDDS) to improve their dissolution rate and oral bioavailability. Nanosuspension was prepared by liquid anti-solvent precipitation method, involving supersaturation of a…
Read More...
Read More...
Recent advances in colon drug delivery systems
As a result of its ability to target certain drugs and/or peptides to the colonic region for the treatment of several diseases while avoiding systemic absorption and potential side effects, colon drug delivery has become a field of research of growing interest. Developing new pharmaceutical…
Read More...
Read More...
Zero-order drug delivery: State of the art and future prospects
Pharmaceutical drugs are an important part of the global healthcare system, with some estimates suggesting over 50% of the world's population takes at least one medication per day. Most drugs are delivered as immediate-release formulations that lead to a rapid increase in systemic drug…
Read More...
Read More...
Acyclovir-Loaded Solid Lipid Nanoparticles: Optimization, Characterization and Evaluation of Its…
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infection. Its oral bioavailability is low; therefore, frequent and high doses are prescribed for optimum therapeutic efficacy. Moreover, the current therapeutic regimen of acyclovir is associated with unwarranted adverse…
Read More...
Read More...
Use of calcium carbonate as an excipient for release of poorly water soluble drugs: The case of…
Carbamazepine (CBZ) is a poorly water soluble drug owing to the Biopharmaceutic Classification System (BCS) class II. It is characterized by a variable bioavailability and by the presence of different polymorphs. In this paper the effects of CaCO3 on the physicochemical properties of CBZ and its…
Read More...
Read More...
Determining the Best Poloxamer Carrier for Thiocolchicoside Solid Dispersions
Industrial pharmacists make many attempts to enhance the solubility of drugs economically. Among the various approaches for enhancing solubility, the solid dispersion (SD) approach is gaining in importance as it is simpler and requires less effort than the other approaches.1
Thiocolchicoside…
Read More...
Read More...
Controlled Release of Metformin Hydrochloride for Improving the Oral Bioavailability Based on a…
This paper demonstrated that a novel enteric osmotic pump capsule (EOPC) could effectively deliver metformin hydrochloride (MH) into the small intestine and keep releasing in a sustained manner consistently. The MH EOPC was composed of enteric semipermeable capsule shell and the core prescription…
Read More...
Read More...
Comparison between Conventional and Supersaturable Self-nanoemulsion Loaded with Nebivolol
Nebivolol (NBH) is a third-generation β1-blocker with high selectivity and vasodilation activity. Nevertheless, nebivolol exhibits low oral bioavailability, which may adversely affect its efficacy. Recently, supersaturable self-nanoemulsion (Su-SNE) is an advanced SNE approach that can address low…
Read More...
Read More...
Solid Dispersion Pellets: An Efficient Pharmaceutical Approach to Enrich the Solubility and…
Deferasirox (DFX) is an oral iron-chelating agent and classified into class II of the Biopharmaceutics Classification System. Low bioavailability of the drug due to insufficient solubility in physiological fluids is the main drawback of DFX. The idea of the current study was to explore the potential…
Read More...
Read More...