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Bioavailability enhancement
Design and In Vitro Evaluation of Solid SEDDS for Breast Cancer Therapy
Lipid-based drug delivery systems have been used as a useful tool for the formulation of hydrophobic drugs giving us the opportunity to enhance permeation from biological membranes, protecting active ingredients from harsh in vivo environment, thus enhancing the bioavailability. Self-emulsifying…
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An Investigation into the Influence of Process Parameters and Formulation Variables on Compaction…
Liquisolid technology, as a promising approach for bioavailability enhancement, has received increasing attention in recent years. However, literature reports addressing the challenges for its industrial application, particularly those related to compaction behavior of liquisolid systems, are…
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Preparation and in vitro characterization of rosuvastatin calcium incorporated methyl beta…
Despite being the most effective hypolipidemic agent, poor physicochemical properties of Rosuvastatin calcium (RCa) remain challenging obstacles in the development of pharmaceutical dosage forms. Inclusion complexes (ICs) of RCa with cyclodextrin (CD) derivatives; methyl-beta-cyclodextrin (M-β-CD)…
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Novel high-drug-loaded amorphous dispersion tablets of posaconazole
Amorphous solid dispersions (ASDs) can increase bioavailability of drugs with poor aqueous solubility. However, concentration-sustaining dispersion polymers (CSPs) incorporated in ASDs can result in low drug loading and therefore large dosage-form size or multiple units to meet dose requirements,…
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Polymer Selection for Hot-Melt Extrusion Coupled to Fused Deposition Modelling in Pharmaceutics
Three-dimensional (3D) printing offers the greatest potential to revolutionize the future of pharmaceutical manufacturing by overcoming challenges of conventional pharmaceutical operations and focusing design and production of dosage forms on the patient’s needs. Of the many technologies…
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Novel analytical approaches for solid dispersion characterization
The overall aim of the thesis was to introduce new analytical techniques to characterize solid dispersion formulations. Solid dispersion formulations are employed to enhance the dissolution behavior and apparent solubility of poorly soluble compounds. This formulation strategy uses typically an…
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Hybridized nanoamorphous micellar dispersion using a QbD–DM3 linked rational product design strategy…
A QbD-DM3 linked rational product design strategy was adopted to create a hybridized ritonavir (RTV, BCS Class IV) nanoamorphous micellar dispersion (RTV-NAD). A DM3 research strategy was employed in conjunction with the quality-by-design spaces, and quality target product profile to link the…
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A review on developments and prospects of anti-inflammatory administration in microemulsions
Anti-inflammatory drugs often cause diverse side effects and have high lipophilicity, therefore there is a need to search for new anti-inflammatory agents or new drug delivery systems (NDDS) that improve their characteristics. Thus, microemulsions (ME) appear as a good hydrophilic and hydrophobic…
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Studies on the in vitro ion exchange kinetics and thermodynamics and in vivo pharmacokinetics of the…
The short half-life and bitter taste of carbinoxamine maleate (CAM) lead to poor compliance by pediatric patients who are being treated for allergic rhinitis. To address these issues, carbinoxamine-resin complexes (CRCs) were prepared by ion exchange and then coated with Kollicoat SR 30D. The…
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Enhancing Oral Bioavailability of Apigenin Using a Bioactive Self-Nanoemulsifying Drug Delivery…
Apigenin (APG) is a very well-known flavonoid for its anti-inflammatory and anticancer properties. The purpose of this study is to improve the solubility and bioavailability of APG using a stable bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS). APG was incorporated in an oil phase…
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