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Bioavailability enhancement
Eutectic mixtures as an approach to enhance solubility, dissolution rate and oral bioavailability of…
Eutectic mixtures have been known for a long time in the pharmaceutical field. However, its potential as a system to improve the solubility and dissolution of poorly water-soluble drugs remains little explored. Studies involving the microstructural characterization and the preparation of solid…
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Preparation, characterization and improved release profile of ibuprofen-phospholipid association
Ibuprofen is a widely prescribed non-steroidal and anti-inflammatory drug, which is practically insoluble in water and causes gastrointestinal (GI) side effects. Ibuprofen-phosphathidylcholine association (IPA) was prepared by refluxing ibuprofen and phosphathidylcholine in three different molar…
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Role of excipients in amorphous solid dispersions
Solid dispersions – a great way to increase the solubility and bioavailability of your drug
In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility and bioavailability. BASF offers both an comprehensive portfolio…
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Nanomedicine and Chemotherapeutics Drug Delivery: Challenges and Opportunities
Cancer is considered as one of the biggest threats to human worldwide. Researchers suggest that tumour is not just a single mass, it comprises cancerous cells surrounded by noncancerous cells such as immune cells, adipocytes, and cancer stem cells (CSCs) in the extracellular matrix (ECM) contains…
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Supercritical Antisolvent Process for Pharmaceutical Applications: A Review
The supercritical antisolvent (SAS) technique has been widely employed in the biomedical field, including drug delivery, to obtain drug particles or polymer-based systems of nanometric or micrometric size. The primary purpose of producing SAS particles is to improve the treatment of dierent…
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Amorphous solid dispersion dry powder for pulmonary drug delivery: Advantages and challenges
Amorphous solid dispersion (ASD) is commonly used in pharmaceutical industry. It has been mainly employed to enhance the oral bioavailability of poorly water-soluble drugs that belong to class II and IV of the biopharmaceutical classification system but has showed promise in other areas of…
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Design of telmisartan-weak acid solid dispersion to improve its solubility and stability
Telmisartan (TEL), an angiotensin II receptor antagonist, is widely used for the treatment of hypertension. However, low solubility of TEL has resulted in solubilized commercial products with alkalizers. On the contrary, our study aims to improve the solubility and dissolution rate by preparing a…
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Crystallization inhibition for enhanced bioavailability – BASF functional solutions for solid and…
Crystallization inhibition is an important factor to maintain drug solubility and bioavailability out of solid and liquid dosage forms in particular. BASF offers a range of well established crystallization inhibitors that ensure that your drug will not get lost on its way to the point of action in…
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Polymeric Precipitation Inhibitor Assisted Supersaturable SMEDDS of Efavirenz Based on Experimental…
Supersaturable SMEDDS, a versatile dosage form, was investigated for improving the biopharmaceutical attributes and eradicating the food effect of poorly water soluble drug efavirenz.
Objective: The present research pursues development of efavirenz loaded supersaturable self-microemulsifying drug…
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Piroxicam ternary solid dispersion system for improvement of dissolution (%) and in vitro…
The improvement of drug solubility is a challenging task in the pharmaceutical industry; moreover, drug stability is also important. This study was designed to improve the dissolution (%) and in vitro anti-inflammation effects of piroxicam (PRX) and maintain its stability using a ternary solid…
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