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Bioavailability enhancement
Asahi Kasei Providing Samples of Hyaluronic Acid Nanogel as a New Pharmaceutical Excipient
Advancing toward commercialization as base material for drug delivery systems
August 04, 2020 10:00 PM Eastern Daylight Time
TOKYO--(BUSINESS WIRE)-- Asahi Kasei has established industrial manufacturing technology for hyaluronic acid (HA) nanogel* as a new pharmaceutical…
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New Research Reveals a Promising Functional Alternative to Surfactants within Biologic Formulations
One of the most common challenges when formulating biological molecules for therapeutic use is overcoming the molecules’ tendency to aggregate. Currently, the nonionic surfactants polysorbate 80 and polysorbate 20 are widely used to stabilize proteins in liquid preparations for parenteral…
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Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability:…
The traditional Chinese medicine, diosgenin (Dio), has attracted increasing attention because it possesses various therapeutic effects, including anti-tumor, anti-infective and anti-allergic properties. However, the commercial application of Dio is limited by its extremely low aqueous solubility and…
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Effect of TPGS surfactant on dissolution sensitivity of a poorly water-soluble drug using high-shear…
d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been widely used in a variety of oral applications to enhance dissolution, solubility, and/or bioavailability of poorly-water soluble drugs. In addition, the use of TPGS could potentially minimize achlorhydric effects typically existing in…
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Emerging insights on drug delivery by fatty acid mediated synthesis of lipophilic prodrugs as novel…
Many drug molecules that are currently in the market suffer from short half-life, poor absorption, low specificity, rapid degradation, and resistance development. The design and development of lipophilic prodrugs can provide numerous benefits to overcome these challenges. Fatty acids (FAs), which…
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Boosting drug bioavailability in men but not women through the action of an excipient
Active pharmaceutical ingredients are routinely formulated with a range of excipients in the manufacture of drug products. Excipients are considered to be inert components of the formulations, although recent research has contested its inactive behaviour. This study investigated the effect of the…
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Hot-Melt Extrusion – Enabling Technologies from Dupont
"Hot melt extrusion (HME), a manufacturing technique traditionally used in the plastic and food industries, is now attracting significant interest from the pharmaceutical manufacturing sector. This is primarily because HME enables the continuous manufacture of a wide variety of dosage…
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Tabletting Solid Dispersions of Bicalutamide Prepared Using Ball-milling or Supercritical Carbon…
The studies were aimed at formulating tablets containing bicalutamide-PVP K-29/32 solid dispersions and accessing the interrelationships between the properties of obtained binary systems in the form of powder and compacts. The effect of the compression of the solid dispersions obtained by either…
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A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems
Drug delivery technology has a wide spectrum, which is continuously being upgraded at a stupendous speed. Different fabricated nanoparticles and drugs possessing low solubility and poor pharmacokinetic profiles are the two major substances extensively delivered to target sites. Among the colloidal…
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Semi-Phyto Universal Solubilizer (SPUS) for enhancing solubility and bio availability of Bioactive…
Aqueous Solubility of Bio actives plays a significant role in Drug, Biopharma, Food, Dietary and Cosmetic formulations. Poor solubility is one of the biggest hurdles in developing these formulations as well as desired therapeutic effect. It is well proven that more aqueous soluble means rapid…
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