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Bioavailability enhancement
Silica nanoparticles: A promising platform for enhanced oral delivery of macromolecules
Oral ingestion remains as the most convenient route of administration for the application of pharmaceuticals since it is non-invasive and does not require trained personnel to administer the drugs. Despite significant progress in novel oral drug delivery platforms over the past few decades, the oral…
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Selection of suitable polymer and obtaining new amorphous solid dispersions with ferulic acid and…
Ferulic acid (FA) is a substance with promising activities, however, its limited aqueous solubility impairs the obtaining of new formulations. Several technological strategies have been developed to increase the solubility of drugs, among which there are amorphous solid dispersions (ASD). Thus, the…
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Solubility and oral bioavailability enhancement: Gelucire® 48/16 pellets
Gelucire 48/16 is a non-ionic surfactant recommended for use in Lipid-Based Formulations (LBFs) to increase aqueous solubility and oral bioavailability of poorly soluble active ingredients. It is a PEG 32 ester lipid excipient comprising a mixture of stearic and palmitic acid monoesters and…
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Microwave-Induced In Situ Amorphization: A New Strategy for Tackling the Stability Issue of…
The thermodynamically unstable nature of amorphous drugs has led to a persistent stability issue of amorphous solid dispersions (ASDs). Lately, microwave-induced in situ amorphization has been proposed as a promising solution to this problem, where the originally loaded crystalline drug is in situ…
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How to improve API Bioavailability?
Today, poor solubility of New Chemical Entities is one of the most frequent and greatest challenges for formulators in the development of oral solid dosage forms. Improving API solubilization is thus of interest to increase bioavailability.
Have a look at SEPPIC's newest solutions for…
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Self-emulsifying excipient for solubility and oral bioavailability enhancement: Gelucire® 44/14
Gelucire® 44/14 is a non-ionic water dispersible surfactant recommended for use in lipid-based formulations to increase the aqueous solubility and oral bioavailability of poorly water soluble drugs.
A multi-component excipient
Gelucire® 44/14 is obtained by an alcoholysis reaction between…
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An investigation into the bioavailability of a peroral cannabinoid-Pheroid® formulation
Cannabidiol (CBD), a phytocannabinoid isolated from the Cannabis sativa plant, has been investigated for its medicinal properties including anti-psychotic, anti- emetic, anti-inflammatory, anxiolytic and anti- convulsant effects1,2. However, the per oral CBD bioavailability has been shown to be only…
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Improved oral bioavailability and target delivery of 6-Shogaol via Vitamin E TPGS-modified…
6-Shogaol is one component of ginger, which has been described to possess various health-promoting effects including anticancer, anti-inflammatory, antioxidant and antiatherogenic. However, poor water solubility has limited the aforementioned health benefits and clinical applications of the drug.…
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Development of a mini-tablet-in-capsule dosage form for macromolecular drug delivery
Oral delivery of protein and peptide drugs faces immense challenges, partially due to the inherent unfavourable characteristics of the molecules and partially due to the unfavourable gastrointestinal environment. These barriers to oral protein drug delivery include the large molecular size,…
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Solid lipid nanocarriers diffuse effectively through mucus and enter intestinal cells – but where is…
Peptides are therapeutic molecules with high potential to treat a wide variety of diseases. They are large hydrophilic compounds for which absorption is limited by the intestinal epithelial border covered by mucus. This study aimed to evaluate the potential of Hydrophobic Ion Pairing combined with…
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