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Bioavailability enhancement
A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology…
Cannabidiol (CBD), a phytocannabinoid compound of Cannabis sativa, shows limited oral bioavailability due to its lipophilicity and extensive first-pass metabolism. CBD is also known for its high intra- and inter-subject absorption variability in humans. To overcome these limitations a novel…
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Nanostructured lipid carriers as oral delivery systems for improving oral bioavailability of…
The aim of this study was to fabricate nanostructured lipid carriers, NLCs, of nintedanib (BIBF) to improve its oral bioavailability. Two types of NLCs loaded with BIBF (BIBF-NLCs-1 and BIBF-NLCs-2) were prepared by the melt-emulsification technique. BIBF-NLCs-1 and BIBF-NLCs-2 showed nanoscale…
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In Vitro-In Silico Evaluation of Apremilast Solid Dispersions Prepared via Corotating Twin Screw…
Highlights
• Solubility enhancement of Apremilast using Hot melt extrusion technology via Corotating Twin Screw Extruder.
• Theoretical and experimental determination of drug-polymer miscibility.
• Influence of Extruder processing parameters on the dispersions and evaluation of stress…
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Mechanodegradation of polymers: a limiting factor of mechanochemical activation in the production of…
In this study we report on the influence of mechanochemical activation on the chemical stability of amorphous solid dispersions made up of indomethacin and HPMC, PVP, PVPVA or Soluplus®. In agreement with our recently published work, all applied carriers were found to be prone to chemical…
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In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous…
Lipid-based formulations can circumvent the low aqueous solubility of problematic drug compounds and increase their oral absorption. As these formulations are often physically unstable and costly to manufacture, solidification has been suggested as a way to minimize these issues. This study…
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Polymeric Materials to Improve the Stability and Delivery of Insulin and Glucagon
Proteins and peptides have become an important class of therapeutics due to their high specificity and general biocompatibility. However, using proteins and peptides as drugs has several intrinsic challenges. These macromolecules are generally cleared rapidly due to renal filtration and enzymatic…
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The design and development of high drug loading amorphous solid dispersion for hot-melt extrusion…
Amorphous solid dispersion (ASD) is a formulation strategy extensively used to enhance the bioavailability of poorly water soluble drugs. Despite this, they are limited by various factors such as limited drug loading, poor stability, drug-excipient miscibility and the choice of process platforms. In…
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Investigating the Potential of Transmucosal Delivery of Febuxostat from Oral Lyophilized Tablets…
Gout is the most familiar inflammatory arthritis condition caused by the elevation of uric acid in the bloodstream. Febuxostat (FBX) is the latest drug approved by the United States Food and Drug Administration (US FDA) for the treatment of gout and hyperuricemia. FBX is characterized by low…
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Amelioration of lipophilic compounds in regards to bioavailability as self-emulsifying drug delivery…
High lipophilicity and poor aqueous solubility are the endemic problems of new drug molecules. Sixty to seventy percent of these drugs are unable to solubilize completely in aqueous media, or have very low permeability. This hampers their oral absorption and further leads to their poor…
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Enhanced Oral Bioavailability of Felodipine from Solid Lipid Nanoparticles Prepared Through…
Felodipine (FLD), a dihydropyridine calcium channel blocker with excellent antihypertensive effect, is poorly soluble and undergoes extensive hepatic metabolism, which lead to poor oral bioavailability (about 15%) and limit its clinic application. The goal of this study was to develop solid lipid…
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