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Bioavailability enhancement
Solving the Insoluble with AFFINISOL™ HPMC
AFFINISOL™ hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement by maintaining stable solid dispersions and inhibiting API crystallization.
More sophisticated drug discovery techniques have led to pipeline compounds that require…
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Properties of κ-carrageenan aerogels prepared by using different dissolution media and its…
Highlights
Kappa-carrageenan aerogel materials were successfully prepared by dissolution into ionic liquids.
Dissolution into ionic liquids allows for a lower volume shrinkage with repercussions on the porosity of the aerogels.
Aerogel matrixes prepared by dissolution into ionic liquids…
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Degrees of order: A comparison of nanocrystal and amorphous solids for poorly soluble drugs
Poor aqueous solubility is currently a prevalent issue in the development of small molecule pharmaceuticals. Several methods are possible for improving the solubility, dissolution rate and bioavailability of Biopharmaceutics Classification System (BCS) class II and class IV drugs.
Two solid state…
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QbD aided development of ibrutinib-loaded nanostructured lipid carriers aimed for lymphatic…
Ibrutinib (IBR) is the choice of drug for the treatment of chronic lymphocytic leukaemia (CLL) and mantle cell lymphoma (MCL). IBR has low oral bioavailability of 2.9% owing to its high first pass metabolism. Present study was aimed to develop the nanostructured lipid carriers (NLC) using glyceryl…
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Recent advances in polymeric drug delivery systems
Polymeric drug delivery systems have been achieved great development in the last two decades. Polymeric drug delivery has defined as a formulation or a device that enables the introduction of a therapeutic substance into the body. Biodegradable and bio-reducible polymers make the magic possible…
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Excipients for Solubility and Bioavailability Enhancement
Active pharmaceutical ingredients (APIs) exhibiting low aqueous solubility or poor intestinal permeability will be associated with poor or variable drug absorption. Lipid-based drug delivery (LBDD) has emerged as a successful approach to improve drug solubilization in the dosage form and, more…
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Amorphous Solid Dispersions in Early Stage of Formulation Development: Predicting Excipient…
Excipients play an important role in the formulation of dosage forms and can be used to improve the bioavailability of a drug through physical interactions that alter the rate of dissolution of a drug. The objective of this study was to predict the effect of formulation on the dissolution rate of a…
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Hot melt extruded zein for controlled delivery of diclofenac sodium: Effect of drug loading and…
This study evaluates the potential use of zein as an excipient in hot-melt extrusion for controlled delivery of diclofenac sodium (DS). Mixtures of zein, polyethylene glycol and drug were hot melt extruded and cut into 2 mm extrudates. Extrudates were characterised using differential scanning…
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Hot Melt Coating of Amorphous Carvedilol
The use of amorphous drug delivery systems is an attractive approach to improve the bioavailability of low molecular weight drug candidates that suffer from poor aqueous solubility. However, the pharmaceutical performance of many neat amorphous drugs is compromised by their tendency for…
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Application of Captisol® Technology to Enable the Formulation of Remdesivir in Treating COVID-19
James Pipkin, PhD, Vince Antle, PhD, and Rebecca Garcia-Fandiño, PhD, explain why more Captisol® than ever is required to meet Gilead’s bold goals of making remdesivir available to COVID-19 patients in the US and to hundreds of countries around the world. Check the full article on drug-dev.com…
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