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Bioavailability enhancement
Formulation and evaluation of luteolin supersaturatable self-nanoemulsifying drug
The current investigation was aimed to enhance the solubility and oral bioavailability of luteolin by employing the supersaturable self-nanoemulsifying drug delivery system(S-SNEDDS). The formulation for SNEDDS consisted of caprylic/capric triglyceride, polyoxyl 35 hydrogenated castor oil and…
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Advanced formulations “supersaturating drug delivery systems” – A video by UNGAP
An UNGAP video further focussing on specific intraluminal behavior of advanced formulations such as supersaturating drug delivery systems, nanoparticles, and lipid-based and controlled release formulations.
About
Oral administration is the most common drug delivery route. Absorption of a…
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Self-Generating nano-emulsifying technology for alternatively-routed, bioavailability enhanced…
The self-generating nano-emulsifying drug delivery system (SNEDDS) is among the most effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of a hydrophobic or poorly-water soluble drug. The methodology for SNEDDS preparation has been established on a number of…
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Exploring the feasibility of biopolymers as potential carriers in the formulation of amorphous solid…
Adequate aqueous solubility of active pharmaceutical ingredients (APIs) is a crucial factor for therapeutic effectiveness. Today, more than fifty percent of the new potential APIs are exhibiting poor aqueous solubility/dissolution rate, leading to low and erratic absorption from the…
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Central Composite Design-Based Optimization of Lopinavir Vitamin E-TPGS Micelle: In Vitro…
Highlights
• Lopinavir was successfully loaded into Vitamin E-TPGS micelles.
• Micelle were prepared by thin film hydration technique.
• Polymer concentration and rotational speed are key parameters in micelle preparation.
• Aqueous solubility of Lopinavir was enhanced by 2.6…
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Zein-based micro- and nano-constructs and biologically therapeutic cues with multi-functionalities…
The selection of polymer with biologically tunable functionalities is a key point for its suitable application. Natural polymers (especially proteins) are preferred over synthetic counterparts, in this regard. Zein is a natural protein obtained from maize (corn) having useful characteristics…
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Enhanced Intestinal Absorption of Insulin by Capryol 90
Labrasol® is a self-emulsifying excipient that contains saturated polyglycolysed C6–C14 glycerides and this additive is known to improve the intestinal absorption of poorly absorbed drugs after oral administration. However, the effects of formulations similar to Labrasol® on the intestinal…
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3D-printed microfluidic chip for the preparation of glycyrrhetinic acid-loaded ethanolic liposomes
18-α-Glycyrrhetinic acid (GA) is a bioactive compound extracted from licorice that exhibits many biological and pharmacological effects such as anti-inflammatory and antioxidant activities on the skin. However, its lipophilic nature results in poor bioavailability that limits clinical applications.…
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Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of…
Silica-lipid hybrid (SLH) microparticles are a solidified lipid-based drug delivery system under investigation for their aptitude to enhance the oral bioavailability of poorly water-soluble drugs. The cholesterol-lowering agent, simvastatin (SIM), is poorly water-soluble and undergoes extensive…
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Nanoencapsulation approaches for oral delivery of vitamin A
Vitamin A is essential to human health. Encapsulation in lipid nanoparticles was used to overcome vitamin A poor water solubility in beverages. This work aimed to develop and characterize lipid nanoparticles, containing vitamin A, for food fortification, assuring its stability and oral…
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