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Bioavailability enhancement
Impact of the polymer dispersity on the properties of curcumin/polyvinylpyrrolidone amorphous solid…
Amorphous solid dispersions (ASD) are known to enhance the absorption of poorly water-soluble drugs. In this work we synthesise well-defined Polyvinylpyrrolidone (PVP) to establish the impact of dispersity and chain-end functionality on the physical properties of Curcumin (CUR)/PVP ASD.…
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Solid dispersions of bedaquiline fumarate to improve its pharmaceutical attributes: A comparative…
Abstract
Objectives
The therapeutic delivery of hydrophobic drugs via solid dispersion is an appealing methodology to enhance the dissolution rate and ultimately the in vivo bioavailability. The objective of current investigation was to enhance the solubility of anti-tubercular drug bedaquiline…
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Self-Emulsifying Drug Delivery System for Enhanced Oral Delivery of Tenofovir: Formulation,…
Tenofovir (TNF) is a common component of many antiretroviral therapy regimens, but it is associated with poor membrane permeability and low oral bioavailability. To improve its oral bioavailability and membrane permeability, a self-emulsifying drug delivery system (SEDDS) was developed and…
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De novo development of small cyclic peptides that are orally bioavailable
Abstract
Cyclic peptides can bind challenging disease targets with high affinity and specificity, offering enormous opportunities for addressing unmet medical needs. However, as with biological drugs, most cyclic peptides cannot be applied orally because they are rapidly digested and/or display low…
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In Vitro and Biological Evaluation of Oral Fast-Disintegrating Films Containing Ranitidine HCl and…
Flurbiprofen (FBP), a nonsteroidal anti-inflammatory drug (NSAID), is commonly used to treat the pain of rheumatoid arthritis, but in prolonged use it causes gastric irritation and ulcer. To avoid these adverse events of NSAIDs, the simultaneous administration of H2 receptor antagonists such as…
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In Vitro and In Vivo testing of 3D-Printed Amorphous Lopinavir Printlets by Selective Laser…
The aim of this paper was to investigate the effects of formulation parameters on the physicochemical and pharmacokinetic (PK) behavior of amorphous printlets of lopinavir (LPV) manufactured by selective laser sintering 3D printing method (SLS). The formulation variables investigated were…
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Oral Self-Nanoemulsifying System Containing Ionic Liquid of BX795 Is Effective against Genital HSV-2…
BX795 is an emerging drug candidate that has shown a lot of promise as a next-generation non-nucleoside antiviral agent for the topical treatment of herpes simplex virus type-1 (HSV-1) and herpes simplex virus type-2 (HSV-2) infections. Our studies indicated that BX795 has limited oral…
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Multilevel categoric factorial design for optimization of raloxifene hydrochloride solid dispersion…
Raloxifene Hydrochloride (RLH) is a selective estrogen receptor modulator (SERM) used for the treatment and prevention of postmenopausal osteoporosis. This Active Pharmaceutical Ingredient (API) belongs to class II biopharmaceutics classification system (BCS) hence it is characterized by…
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Electromechanical convective drug delivery devices for overcoming diffusion barriers
Abstract
Drug delivery systems which rely on diffusion for mass transport, such as hydrogels and nanoparticles, have enhanced drug targeting and extended delivery profiles to improve health outcomes for patients suffering from diseases including cancer and diabetes. However, diffusion-dependent…
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A Quality by Design Approach for Developing SNEDDS Loaded with Vemurafenib for Enhanced Oral…
Vemurafenib (VMF) is a practically insoluble (< 0.1 μg/mL) and least bioavailable (1%) drug. To enhance its oral bioavailability and solubility, we formulated a reliable self-nano emulsifying drug delivery system (SNEDDS). A Quality by Design (QbD) approach was used to optimize the ratio of…
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