Capsules are a popular dosage form in the pharmaceutical industry because they provide an easy and convenient way to administer medications, offering precise dosage control. They can be formulated to contain a variety of active ingredients, including powders, liquids, and pellets, and can also be designed for immediate or extended release. Capsules protect sensitive drugs from environmental factors like light and air, enhancing drug stability and patient adherence.
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Capsules
Enteric Hard Capsules for Targeting the Small Intestine: Positive Correlation between In Vitro…
In this study, the potential for correlation between disintegration and dissolution performance of enteric-coated (EC) dosage forms was investigated. Different enteric hard shell capsule formulations containing caffeine as model drug were tested for disintegration (in a compendial disintegration…
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DRcaps® Capsules Achieve Delayed Release Properties for Nutritional Ingredients in Human Clinical…
Probiotics and enzymes are sensitive to acid and run the risk of being rendered less effective while crossing the low pH of the stomach on their way to the intestinal tract. That is why, Capsugel® performed a gamma-scintigraphy study that confirms delayed release properties of Capsugel® DRcaps™…
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Evaluation on Biorelevant Dissolution Behavior of Propranolol HCl Encapsulated in Various Capsules
Two-piece hard capsules continuously serve as widely used oral drug and dietary supplement dosage forms. Hard gelatin capsules are used in 20% of all oral dosage forms but have numerous shortcomings especially with potential crosslinking with the active ingredient, the growing consumer preference…
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LYCAGEL™ – Roquette’s Innovative Plant-Based Solution Unlocks Possibilities for Veggie Softgel…
Market-first plant-based softgel system provides a strong alternative to gelatin for nutraceutical and pharmaceutical manufacturers and marketers of softgel products
GENEVA, Illinois. (November 18, 2020) - Roquette, a global leader in plant-based ingredients, pioneer of plant proteins and…
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Controlled Release of Metformin Hydrochloride for Improving the Oral Bioavailability Based on a…
This paper demonstrated that a novel enteric osmotic pump capsule (EOPC) could effectively deliver metformin hydrochloride (MH) into the small intestine and keep releasing in a sustained manner consistently. The MH EOPC was composed of enteric semipermeable capsule shell and the core prescription…
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Accordion Pill®: Laminated, folded, encapsulated
So much for capsules can only be filled with powders, pellets, microtablets or liquids! The Accordion Pill® by Intec Pharma Ltd. is a drug delivery system that uses active ingredient containing polymeric films, which are folded into an undulated shape. This system combines an efficient gastric…
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In Vitro Evaluation of Enteric-Coated HPMC Capsules – Effect of Formulation Factors on Product…
A comparative study on different enteric-coated hard capsules was performed. The influence of different formulation factors like choice of enteric polymer, triethyl citrate (TEC) concentration (plasticizer), talc concentrations (anti-tacking agent), and different coating process parameters on the…
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Suitability of phosphatidylcholine-based formulations for liquid filling in hard capsules
The current study aimed to evaluate whether phosphatidylcholine-based formulations have suitable properties for liquid filling in hard capsules. Liquid or semisolid formulations were obtained with Miglyol 812 (medium chain triglycerides) or Softisan 378 (semisolid hard fat), respectively, in…
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In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it dicult to achieve therapeutic levels…
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Innovation in starter pellets – PharSQ® Spheres CM unique calcium-phosphate based starter…
Drug layering on starter pellets is a standard technology to achieve multiparticulate dosage forms. The most widely used are still sugar spheres / non-pareils but also neutral pellets made of microcrystalline cellulose such as Cellets are applied. Although not a lot of new starter pellets have come…
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