Capsules are a popular dosage form in the pharmaceutical industry because they provide an easy and convenient way to administer medications, offering precise dosage control. They can be formulated to contain a variety of active ingredients, including powders, liquids, and pellets, and can also be designed for immediate or extended release. Capsules protect sensitive drugs from environmental factors like light and air, enhancing drug stability and patient adherence.
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Capsules
Development of a mini-tablet-in-capsule dosage form for macromolecular drug delivery
Oral delivery of protein and peptide drugs faces immense challenges, partially due to the inherent unfavourable characteristics of the molecules and partially due to the unfavourable gastrointestinal environment. These barriers to oral protein drug delivery include the large molecular size,…
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Enteric-coated HPMC capsules: Comparison of enteric coatings and investigation of relationship…
Polymeric film coating of oral solid dosage forms may generate products that exhibit controlled release of active ingredients, physical and chemical protection of the ingredients from the external environment as well as taste masking properties. Among controlled release products, sustained and…
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Age-Appropriate Solid Oral Formulations for Pediatric Applications with a Focus on Multiparticulates…
This paper presents the output of a workshop held at the 11th Annual Conference of EuPFI (European Paediatric Formulation Initiative), in September 2019 in Malmo, Sweden, on the development of multiparticulates and minitablets as pediatric formulations. The workshop focused on three specific facets…
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Moisture sorption and desorption properties of gelatin, HPMC and pullulan hard capsules
The moisture sorption and desorption properties of hard capsules have a great influence on the quality of capsule products. However, studies on them have rarely been reported. Herein, we studied the moisture sorption and desorption properties of three kinds of hard capsules (gelatin, hydroxypropyl…
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Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status,…
Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell.
This is of increasing interest in drug delivery applications.…
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Semisolid-filled Capsules of Carvedilol for Improving Dissolution Behaviour
The present investigation was aimed at enhancing the dissolution properties of carvedilol, a poorly water-soluble drug using a combination of solid dispersion and semisolid-filled capsule. The use of lauroyl polyoxyl-6 glycerides as a carrier in a semisolid base to improve the dissolution behaviour…
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Gastrointestinal Tracking and Gastric Emptying of Coated Capsules in Rats with or without Sedation…
Following oral administration, gastric emptying is often a rate-limiting step in the absorption of drugs and is dependent on both physiological and pharmaceutical factors. To guide translation into humans, small animal imaging during pre-clinical studies has been increasingly used to localise the…
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Formulation of Ketoconazole Nanocrystal-Based Cryopellets
Commercial development of nanosuspensions for oral drug delivery generally involves a drying step which aims to generate a stable product that rapidly releases the nanocrystals once rehydrated and can be easily processed into a final dosage form (e.g., filled into hard capsule).
Cryopelletisation…
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Development and Evaluation of Controlled and Simultaneous Release of Compound Danshen Based on a…
In the study, we developed a novel oral dosage form of Compound Danshen to resolve the problems of low bioavailability, disequilibrium in drug release, and stomach degradation of active components of Compound Danshen in conventional formulas.
A colon-specific osmotic pump capsule (COPC) of…
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The Role of Excipients in CBD Products
Cannabidiol (CBD) has become an industry panacea that’s finding its way into everything from daily supplements to herbal therapies. The market is thriving, with one in seven US consumers relying on therapeutic CBD oils. The United States spends more than $803 million a year on cannabidiol products.…
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