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Carbomer
Research of the selection of a gelling agent with further saturation of wipes with active prolonged…
Introduction
During our research of the selection of gelling agents followed by saturation of wipes with an active prolonged effect, many factors should be considered. This fact may influence further drug development. The most important characteristics include the physical and chemical properties…
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Design and evaluation of glimepiride hydrogel for transdermal delivery
The solubility of glimepiride (GM) was improved from 1.6 μg/mL to 22.0 mg/mL when GM and meglumine (MU) complexes were prepared. Therefore, transdermal hydrogels of GM Carbopol (GM-CP) and GM hydroxypropyl methylcellulose pullulan (GM-HPMC-Pu) were prepared successfully utilizing the improved drug…
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Exorbitant Drug Loading of Metformin and Sitagliptin in Mucoadhesive Buccal Tablet: In Vitro and In…
The aim of the proposed study is to develop a mucoadhesive buccal delivery system for the sustained delivery of metformin (MET) and sitagliptin (SIT) against diabetes mellitus (DM) with improved bioavailability. Polymeric blend of Carbopol® 940 (CP), agarose (AG) or polyvinylpyrrolidone K30 (PVP) as…
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Nanoemulgel: For Promising Topical and Systemic Delivery
Nanoemulgel delivery system is a fusion of two different delivery systems, wherein the physical state of drug containing nanoemulsion is changed by adding it to the gel matrix, thus enabling more lipophilic drugs to be used in treatment therapies. It solves the major issues such as limiting use of…
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Quantitative Structure-Activity Relationship of Enhancers of Licochalcone A and Glabridin Release…
This study aimed to systematically compare licochalcone A (LicA) and glabridin (Gla) (whitening agents) release and permeation from Carbomer 940 (CP) hydrogels with different enhancers, and evaluate the relationship between the quantitative enhancement efficacy and structures of the enhancers. An in…
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Comparative Study of the Mucoadhesive Properties of Polymers for Pharmaceutical Use
In recent years, mucoadhesive dosage forms due to their advantages have attracted the interest of researchers and developers. Polymeric excipients are included into the drug composition to give adhesion to the mucous membrane.
AIM: The aim of this research was to select a specific brand of…
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Improved skin-permeated diclofenac-loaded lyotropic liquid crystal nanoparticles: QbD-driven…
The purpose of the present study was to optimise diclofenac diethylamine-loaded liquid crystal nanoparticles (LCNPs) using the principles of quality by design. Based on risk assessment, the effect of various formulation variables on the critical quality attributes was investigated. A three-level…
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Comparison of Different Liquid and Semisolid Vehicles Selected for Oral Administration of Pellets…
The acceptability and palatability of a dosage form are extremely important to improve patient compliance. Mixing oral solid dosage forms with food carriers is often necessary to ease swallowing and provide the taste-masking effect. The present research investigated how a liquid or semisolid carrier…
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