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CBD
Improved Transdermal Delivery of Novel Cannabinoid-Loaded Patches Using Eudragit Matrix
The main active cannabinoids in extracts of Cannabis sativa L., cannabidiolic acid (CBDA) and tetrahydrocannabinolic acid (THCA), are known for their pharmacological effects, including anti-inflammatory, analgesic, psychedelic, anti-cancer, and anti-spasmodic activities. This study aimed to develop…
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Fabrication of Orally Fast Disintegrating Wafer Tablets Containing Cannabis Extract Using Freeze…
Abstract
Introduction: The development of a novel dosage form for cannabis extract is necessary to improve drug delivery
and to also enhance patient convenience.
Methods: Orally fast disintegrating wafer tablets containing cannabis extract, which were prepared using the
freeze drying…
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Fabrication and Optimization of Directly Compressible Self-Emulsifying Tablets Containing Cannabis…
Δ9-Tetrahydrocannabinol and cannabidiol, which are present in cannabis extract, exhibit low bioavailability when administered orally due to significant first-pass metabolism. The use of a self-emulsifying drug delivery system (SEDDS) can enhance their dissolution and bioavailability. However, liquid…
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CBD Oil Tablets Chewable – Direct Compression with PROSOLV 730
Aim of the Study
Due to the physico-chemical properties of cannabidiol (CBD), the vast majority of the marketed products containing CBD are oils. To provide greater convenience in dosing, the goal of this experiment was to make directly compressible 25 mg CBD oil tablets as well as 25…
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Combining the potential of 3D printed buccal films and nanostructured lipid carriers for…
Abstract
Cannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some limitations, including unpredictable pharmacokinetics and low oral bioavailability. To overcome the challenges…
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Feasibility study of the use of a homemade direct powder extrusion printer to manufacture printed…
Among the various 3D printing techniques, FDM is the most studied in pharmaceutical research. However, it requires the fabrication of filaments with suitable mechanical properties using HME, which can be laborious and time-consuming. DPE has emerged as a single-step printing technique that can…
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Permeation-Enhancing Strategies for Transdermal Delivery of Cannabinoids
Introduction:
This review aims to provide an overview of the advancements and status of clinical studies and potential permeation-enhancing strategies in the transdermal delivery of cannabinoids.
Methods:
A systematic and comprehensive literature search across academic databases, search…
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Cannabidiol safety considerations: Development of a potential acceptable daily intake value and…
Consumer use of hemp-derived products continues to rise, underscoring the need to establish evidence-based safety guidance. The present study sought to develop recommendations for oral upper intake limits of cannabidiol (CBD) isolate. Sufficiently robust and reliable data for this purpose were…
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Co-Dispersion Delivery Systems with Solubilizing Carriers Improving the Solubility and Permeability…
Cannabinoids: cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabichromene (CBC) are lipophilic compounds with limited water solubility, resulting in challenges related to their bioavailability and therapeutic efficacy upon oral administration. To overcome these limitations, we developed…
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Formulation and quality consideration of cannabidiol printed forms produced by fused-deposition…
Introduction
Cannabidiol (CBD) is a promising non-psychoactive cannabinoid that shows several clinical outcomes. Commercially, this molecule is used in Epidiolex® (Greenwich Biosciences, Inc), a Food and Drug Administration (FDA)-approved drug to treat Lennox-Gastaut and Dravet syndromes,…
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