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CBD
WITEPSOL® as a carrier of the “Green Rush”
Cannabis was banned almost everywhere on earth for nearly eight decades. But legalisation in many parts of the world triggered a boom in demand. In the meantime, the “green rush” has become a popular term, based on the “gold rush”. Cannabis is known mainly for its intoxicating effects, but it is…
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Part III of the series – Encapsulating cannabinoids in lipid-based nanoparticles: THC vs. CBC
Enhancing cannabinoids’ therapeutic efficacy
In our previous technical note, we reported on the encapsulation of CBD vs THC (1) into lipid-based nanoparticles. The work here-in continues on that theme in terms of studying the differences in encapsulating different cannabinoids into the same…
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Application of a liquisolid technique to Cannabis sativa extract compacts: Effect of liquid vehicles…
This work describes the application of the liquisolid technique to enhance cannabinoid dissolution from Cannabis sativa L. (CS) compacts. The effects of five vehicles, namely, volatile (ethanol) and nonvolatile (caprylocaproyl macrogolglycerides, polyethylene glycol 400, oleoyl macrogolglycerides…
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Development and Pharmacokinetic Evaluation of a Self-Nanoemulsifying Drug Delivery System for the…
The number of lipophilic drug candidates in pharmaceutical discovery pipelines has increased in recent years. These drugs often possess physicochemical properties that result in poor oral bioavailability, and their clinical potential may be limited without adequate formulation strategies.…
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Data-Enriched Edible Pharmaceuticals (DEEP) with Bespoke Design, Dose and Drug Release
Data-enriched edible pharmaceuticals (DEEP) is an approach to obtain personalized medicine, in terms of flexible and precise drug doses, while at the same time containing data, embedded in quick response (QR) codes at a single dosage unit level. The aim of this study was to fabricate DEEP with a…
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White Paper: Refined Sesame Oil IV-1
SIO Presentation
ADM-SIO, is a global manufacturer of injectable-grade pharmaceutical oils - used as API’s or excipients for oil-soluble drugs. We offer an extensive range of highly purified oils, derived from vegetable origins that meet all relevant pharmaceutical regulations and are…
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Pharmaceutical oils for Cannabinoid drug products from ADM-SIO
Medicinal Cannabinoids
There are currently more than 150 cannabinoid-based products under development in the world. The first US FDA approved product Epidiolex®, isolated from the cannabis plant and indicated for severe forms of epilepsy is formulated with Sesame oil. Other approved products like…
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Oil adsorption – The Interview with Fuji Chemical
Fuji Chemical Industries specializes in producing porous spray-dried excipients for the pharmaceutical and nutraceutical markets. They spray-dry their excipients to produce free-flowing granules and unique internal structures that enhance compressibility and functionality. These structures are ideal…
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Simultaneous determination of third-generation synthetic cannabinoids in oral fluids using…
A microporous material made of cyclodextrin units covalently immobilized into a silica network has found an innovative bioanalytical application in the sample clean-up and simultaneous isolation of three synthetic cannabinoids (ADB-CHMICA, MMB-CHMICA, and MDMB-CHMCZCA) from human oral fluid through…
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Encapsulating cannabinoids in lipid-based nanoparticles: THC vs. CBD – Part 2 of the series
Enhancing cannabinoids’ therapeutic efficacy
In our previous technical note, we reported on the encapsulation of CBD vs CBDA (1). The work here-in continues on that theme in terms of studying the differences in encapsulating different cannabinoids into the same lipid-based drug delivery system that…
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