Chitosan is a biopolymer derived from chitin, a natural polymer found in the shells of crustaceans such as shrimp, crabs, and lobsters. It is a linear polysaccharide composed of randomly distributed β-(1→4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit). Chitosan has a range of applications due to its unique physical and chemical properties, including its ability to form films, gels, and beads, and its biocompatibility.
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Chitosan
Formulation and Evaluation of Polysaccharide Microparticles for the Controlled Release of…
Abstract
Propranolol hydrochloride, a non-cardio-selective beta blocker, is used to treat several conditions in children, including hypertension, arrhythmias, hyperthyroidism, hemangiomas, etc. Commercial liquid formulations are available in Europe and the US, but they have disadvantages, such as…
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Chitosan Nanoparticles for Intranasal Drug Delivery
Abstract
This manuscript explores the use of nanostructured chitosan for intranasal drug delivery, targeting improved therapeutic outcomes in neurodegenerative diseases, psychiatric care, pain management, vaccination, and diabetes treatment. Chitosan nanoparticles are shown to enhance brain…
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Carbomer Hydrogels with Microencapsulated α-Tocopherol: Focus on the Biocompatibility of the…
The microencapsulation of α-tocopherol based on the complex coacervation of low-molecular-weight chitosan (LMWC) and sodium lauryl ether sulphate (SLES) without harmful crosslinkers can provide biocompatible carriers that protect it from photodegradation and air oxidation. In this study, the…
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Therapeutic Potential of Nanocarrier Mediated Delivery of Peptides for Wound Healing: Current…
Wound healing presents a complex physiological process that involves a sequence of events orchestrated by various cellular and molecular mechanisms. In recent years, there has been growing interest in leveraging nanomaterials and peptides to enhance wound healing outcomes. Nanocarriers offer unique…
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Shifting from sustained to delayed drug delivery systems: Encapsulated mesoporous silica-chitosan…
The current study demonstrates a desired drug delivery-controlled system with a wide range of release parameters. It illustrates the feasibility of carriers in the systems for extended and short drug release. Herein, mesoporous silica nanoparticles (MSNs) coated with chitosan (Cs) grafted polylactic…
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Design and development of a chitosan-based nasal powder of dimethyl fumarate-cyclodextrin binary…
The nasal administration route has been studied for the delivery of active molecules directed to the Central Nervous System, thanks to the anatomical connection between the nasal cavity and the brain.
Dimethyl fumarate is used to treat relapsing-remitting multiple sclerosis, with a role as an…
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Oral Delivery of Liraglutide-Loaded Zein/Eudragit-Chitosan Nanoparticles Provides Pharmacokinetic…
Abstract
Liraglutide (LIRA) is a glucagon-like peptide-1 (GLP-1) receptor agonist renowned for its efficacy in treating type 2 diabetes mellitus (T2DM) and is typically administered via subcutaneous injections. Oral delivery, although more desirable for being painless and potentially enhancing…
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Nanocarriers for Controlled Release and Target Delivery of Bioactive Compounds
See the new book, edited by Shaba Noore , Shivani Pathania , Pablo Fuciños , Colm P. O'Donnell , Brijesh K. Tiwari.
Description: This brief provides a comprehensive overview of nanocarriers used for nanoencapsulation of bioactive compounds. It includes the basis of encapsulation mechanism,…
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Chitosan-based buccal mucoadhesive bilayer tablets enhance the bioavailability of tizanidine…
Tizanidine hydrochloride (TZN) is an antimuscarinic agent used in the treatment of pain-related spasms, multiple sclerosis, and stroke-related spasticity. It has low oral bioavailability (40 %) due to excessive first-pass metabolism in the liver. The aim of this project was to enhance the systemic…
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In Situ Gelling Nasal Drug Delivery System
Abstract
In the nasal cavity, nasal mucosa had a high blood perfusion rate, due to this the absorption of the drug is high as compared to other routes, as well as has increased good bioavailability of drugs at the systemic circulation. To improve the nasal retention time of in-situ gel with nasal…
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