Chitosan is a biopolymer derived from chitin, a natural polymer found in the shells of crustaceans such as shrimp, crabs, and lobsters. It is a linear polysaccharide composed of randomly distributed β-(1→4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit). Chitosan has a range of applications due to its unique physical and chemical properties, including its ability to form films, gels, and beads, and its biocompatibility.
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Chitosan
Hyaluronic acid modified oral drug delivery system with mucoadhesiveness and macrophage-targeting…
Based on the biocompatibility and macrophage targeting of natural polysaccharides, combined with the physiological and pathological characteristics of the gastrointestinal tract and colonic mucosa of ulcerative colitis (UC), we prepare dexamethasone (Dex)-loaded oral colon-targeted nano-in-micro…
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Microneedle-assisted transdermal delivery of nanoparticles: Recent insights and prospects
Transdermal delivery of drugs offers an interesting alternative for the administration of molecules that present certain troubles when delivered by the oral route. It can produce systemic effects or perform a local action when the formulation exerts an optimal controlled drug release or a targeted…
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Exploring the potential of quercetin/aspirin-loaded chitosan nanoparticles coated with Eudragit L100…
Growing evidence suggests quercetin and aspirin may have anticancer properties, notably in the case of colorectal cancer. The goal of this study was to create Pluronic F127 and polyethylene glycol 4000 solid dispersion-loaded chitosan nanoparticles for colonic quercetin and aspirin delivery. In 1:1…
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Chitosan-Based Nanoparticles with Optimized Parameters for Targeted Delivery of a Specific…
Chitosan is a positively charged polysaccharide obtained through chitin deacetylation. It belongs to a group of biodegradable, bioavailable, and non-toxic materials of natural origin; thus, it is a promising matrix for creating delivery systems of different active agents. Recently, much attention…
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Spray drying and nano spray drying as manufacturing methods of drug-loaded polymeric particles
In this review, benefits and drawbacks of the process of spray drying and nano spray drying with regard to the manufacturing of polymeric particles for pharmaceutical applications are discussed. Spray drying has been used for many years in the food, chemical and pharmaceutical industries for…
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Recent developments in improving the emulsifying properties of chitosan
Chitosan is one of the valuable products obtained from crustacean waste. The unique characteristics of chitosan (antimicrobial, antioxidant, anticancer, and anti-inflammatory) have increased its application in various sectors. Besides unique biological properties, chitosan or chitosan-based…
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Development of Novel pH-Sensitive Eudragit Coated Beads Containing Curcumin-Mesalamine Combination…
This research aims to develop a drug delivery system that effectively treats colitis while administering curcumin/mesalamine by coating alginate/chitosan beads with Eudragit® S-100 to target the colon. Beads were tested to determine their physicochemical characteristics. Coating with Eudragit® S-100…
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Recent Advancement of Molecular Structure and Biomaterial Function of Chitosan from Marine Organisms…
Chitosan is an innate cationic biological polysaccharide polymer, naturally obtained from chitin deacetylation, that possesses broad-spectrum properties such as antibacterial, biodegradability, biocompatibility, non-toxic, non-immunogenicity, and so on. Chitosan can be easily modified owing to its…
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Injectable Chitosan-Based Hydrogels for Trans-Cinnamaldehyde Delivery in the Treatment of Diabetic…
Diabetic foot ulcers (DFU) are among the most common complications in diabetic patients and affect 6.8% of people worldwide. Challenges in the management of this disease are decreased blood diffusion, sclerotic tissues, infection, and antibiotic resistance. Hydrogels are now being used as a new…
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Mucoadhesive Oro-Gel–Containing Chitosan Lipidic Nanoparticles for the Management of Oral Squamous…
Abstract
Purpose
The aim of this research work was to develop a mucoadhesive oro-gel–containing resveratrol loaded folate conjugated chitosan-lipidic nanoparticles (RES-FA-LP-NPs) for targeted delivery to oral squamous cell carcinoma (OSCC).
Method
RES-FA-LP-NPs were prepared by hot…
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