Chitosan is a biopolymer derived from chitin, a natural polymer found in the shells of crustaceans such as shrimp, crabs, and lobsters. It is a linear polysaccharide composed of randomly distributed β-(1→4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit). Chitosan has a range of applications due to its unique physical and chemical properties, including its ability to form films, gels, and beads, and its biocompatibility.
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Chitosan
Non-invasive peptides delivery using chitosan nanoparticles assembled via scalable microfluidic…
The delivery of peptides via non-invasive administration routes remains a challenge to be addressed. In this regard, chitosan nanoparticles (CS NPs) have shown promise. However, their current batch preparation methods (ionotropic gelation, polyelectrolyte complexing, emulsification solvent diffusion…
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Formulation and Characterization of Bilastine Oral Disintegrated Tablets Using Natural and Synthetic…
Bilastine (BLS) is a second-generation H1- antihistamine that is approved recently for the symptomatic treatment of chronic urticaria. The present investigation was to develop oral disintegrating tablets of BLS to produce a fast onset of action. In this study, an attempt was made to compare the…
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Single and Multitarget Systems for Drug Delivery and Detection: Up-to-Date Strategies for Brain…
Abstract
This review summarizes the recent findings on the development of different types of single and multitarget nanoparticles for disease detection and drug delivery to the brain, focusing on promising active principles encapsulated and nanoparticle surface modification and functionalization.…
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Film-Forming Polymers for Inhibition of Hydroxyapatite Dissolution: A Screening Study
The aim of this study was to evaluate the effect of film-forming polymer solutions of different concentrations and pH values, either associated or not with sodium fluoride (F; 225 ppm F−), when applied during the initial stage of salivary pellicle formation, to prevent the dissolution of…
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Orodispersible Films: Current Innovations and Emerging Trends
Abstract
Orodispersible films (ODFs) are thin, mechanically strong, and flexible polymeric films that are designed to dissolve or disintegrate rapidly in the oral cavity for local and/or systemic drug delivery. This review examines various aspects of ODFs and their potential as a drug delivery…
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Recent advances in biopolymer-based mucoadhesive drug delivery systems for oral application
Oral drug delivery is a common and convenient route for administering pharmaceuticals, but it presents challenges related to drug stability, absorption, and targeted delivery. Because of their potential to address these challenges, biopolymer-based mucoadhesive drug delivery systems have received a…
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Experimental design approach for Development of Carboplatin Loaded Chitosan Modified Liposomal…
One of the most prevalent cancers affecting women globally is cervical cancer. Cervical cancer is thought to cause 570.000 new cases annually, and standard treatments can have serious side effects. In this work main aim is to design, fabrication and evaluation of carboplatin loaded chitosan coated…
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Development of famotidine-loaded lecithin-chitosan nanoparticles for prolonged and efficient…
Lecithin-chitosan nanoparticles (LCNPs) represent an appealing nanocarrier for the oral delivery of hydrophobic drugs. Negatively charged lecithin and positively charged chitosan were permitted to interact to create LCNPs. Their distinctive features enable drugs to be encapsulated into the…
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Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery
Polysaccharide aerogels have emerged as a highly promising technology in the field of oral drug delivery. These nanoporous, ultralight materials, derived from natural polysaccharides such as cellulose, starch, or chitin, have significant potential in colonic drug delivery due to their unique…
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Chitosan-coated alginate (CCA) nanoparticles for augmentation of topical antihistaminic activity of…
Abstract
Objective
The aim of the present study was to formulate chitosan-coated alginate nanoparticles containing the drug diphenhydramine hydrochloride (DHH).
Significance
Diphenhydramine hydrochloride (DHH) is the prototype of H1-antihistaminic drugs. It is a lipophilic drug, that…
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