Co-processed excipients

This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melts® type C,M and F1. All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were prepared using three compression pressures. The viscoelastic…
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Introduction Polymers have various applications such as binder, film coating agent, stabilizer, drug release modification and as primary packaging materials. Recently, they have been explored in co-processing technique to improve the functionality of small molecule excipients (SMEs). Co-processing…
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The formulation of orodispersible minitablets (ODMTs) usually targets the disintegration time and mechanical strength, but should also consider a series of technological issues related to powder flow and compression behaviour. In this regard, the present study aimed to evaluate the contribution of…
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HiSORAD is a state-of-the-art co-processed excipient for orally disintegrating tablets designed to have well-balanced property between orally disintegration time and tablet hardness. HiSORAD enables to produce ODTs by direct compression with three advantages: Practical flowability, excellent…
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Sulpiride (SUL) is a dopamine D2-receptor antagonist used for management of GIT disturbance and it has anti-psychotic activities based on the administered dose. SUL undergoes P-glycoprotein efflux, which lead to poor bioavailability and erratic absorption. Therefore, the objective of this research…
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Mini-tablets are solid dosage forms with increasing interest for pharmaceutical industry due to clinical and biopharmaceutical benefits. But technological aspects on mini-tableting are not fully investigated. Therefore, the impact of punch size and tableting pressure for industrially relevant…
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MEGGLE released the new excipient Reta M® at October 13. Pharma Excipients used the chance to do an interview with the responsible product manager, Dr. Christian Nowak, to learn more about Reta M®.  It is the first hypromellose/mannitol-based, co-processed excipient specifically designed for direct…
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Multiple-unit pellet systems (MUPS) oer many advantages over conventional solid dosage forms both for the manufacturers and patients. Coated pellets can be efficiently compressed into MUPS in classic tableting process and enable controlled release of active pharmaceutical ingredient (APIs). For…
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This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melt® type C, M and F1. All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were prepared using three compression pressures. The viscoelastic…
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Orally disintegrating tablets (ODTs) are one of the most popular dosage forms for improving medication adherence. ODTs disintegrate in saliva in the oral cavity without requiring water. This allows patients with dysphagia, as well as geriatric and pediatric populations, to easily swallow the…
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