Co-processed excipients

The aim of this study was the development of lactase tablets that can be produced by direct compression. In order to avoid stability problems of the enzyme lactose, caused by high temperature and moisture, direct compression is the most suitable tableting process. The performance of pure lactase…
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Hydroxypropyl methylcellulose (HPMC) is a frequently used matrix former for controlled release tablets. To adjust desired drug release kinetics, freely water-soluble lactose can be added. The aim of this study was to investigate the importance of the type of preparation technique of propranolol…
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In the manufacture of tablets, especially in direct tableting processes, the flowability of excipient powders and formulated powders is one of the most important characteristics. In the past two decades, orally disintegrating tablets (ODTs) have been prepared as popular solid dosage forms for…
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08. April 2017 Co-processed excipients are expected to play a key role in the production of new chemical entities (NCEs), according to BCC Research. As developing new excipients can be time-consuming and expensive from a safety perspective, manufacturers see…
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Abstract This study has investigated the potential use of zein protein from corn as a pharmaceutical excipient for formulation of oral controlled-release matrices. SMCC (silicified microcrystalline cellulose)-Prosolv® 90 SMCC HD-Prosolv® 90 HD, Avicel® PH 102 and Mannitol 60…
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