Pharma Excipients
Coating Systems and Additives
Quality Deviation Handling on the Polymeric Coating of Pharmaceutical Tablets
This work aimed to map and discuss tablet-coating choice, quality deviations of this process, and corrective actions taken by Research and Development (R&D) teams from pharmaceutical industries.
Methods
A cross-sectional study of polymeric film coating was conducted in Brazil: a questionnaire…
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Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography
The paper presents a new in-line measurement technique for determining the coating thickness and uniformity of pharmaceutical pellets during film-coating in a fluid-bed apparatus. Non-destructive and contact-free process monitoring was performed via an optical coherence tomography (OCT) sensor…
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Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules. However, the information of ATBC on its pharmacokinetics is…
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Measure the coating thickness and characteristics of tablets or pellets
10. June 2018
The focus of the OSeeT are enteric coatings (EC) and modified-release (MR) coatings.
The characteristics of the coating layer are revealed via OSeeT:
Mean coating thickness
→ progress of coating process
Intra-particle and inter-particle…
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Stabilization of Glucagon by Trehalose Glycopolymer Nanogels
23. January 2018
Abstract
Glucagon is a peptide hormone used for the treatment of hypoglycemia; however, its clinical potential is limited by its insolubility and instability in solution. Herein, the encapsulation, stabilization, and release of glucagon by trehalose glycopolymer…
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Extended-release venlafaxine pellets: scaling up – Poster Ashland AAPS 2014
06. December 2015
Introduction:
This study from Ashland was undertaken to investigeate the influence of coating process scale when applying an organic solvent based modified release coating to multiparticulates using a Wurster process.
Download the full poster here…
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The central role of excipients in drug formulation
Active substances are rarely administered alone. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment of hypothyroidism, is administered at a very low dosage, ranging from 15 μg to 200 μg. These very small amounts of powder mean that it is not possible…
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Preparation and characterization of controlled-release doxazosin mesylate pellets using a simple…
Pellets are one of multiparticulate pharmaceutical forms and can offer numerous technical and biopharmaceutical advantages compared with single dose unit formulations, e.g. tablets and capsules. This study aimed at formulation of controlled-release pellets of doxazosin mesylate (DM), a widely used…
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Ashland launches web-based film-coatings troubleshooting tool and new pharmaceutical excipients…
Ashland launches web-based film-coatings troubleshooting tool and new pharmaceutical excipients website.
WILMINGTON, Del. - Formulators are looking for swift, tailored solutions to identify the best film coating for their dosage forms and to better respond to film-coating issues when they arise.…
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Ashland announces global price increase for vinyl pyrrolidone- and cellulosic-based pharmaceutical…
Ashland announces global price increase for vinyl pyrrolidone- and cellulosic-based pharmaceutical excipient products
WILMINGTON, Del. - Ashland Specialty Ingredients, a commercial unit of Ashland Inc. (NYSE: ASH), is increasing the price of its portfolio of Aqualon™ ethylcellulose and sodium…
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