Coating Systems and Additives

The feasibility of Optical Coherence Tomography (OCT) for in-line monitoring of pharmaceutical film coating processes has recently been demonstrated. OCT enables real-time acquisition of high-resolution cross-sectional images of coating layers and computation of coating thickness. In addition,…
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Purpose Drug X is high solubility, high permeability BCS/DCS I small molecule drug. High dose and potential pediatric indication required multiparticulate formulation with not less than 80% drug loading to achieve flexible and low quantity dosing with potential for modified release…
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The objectives of this study are the development and evaluation of modified release multi-particulate drug delivery systems containing a BCS class II drug (meloxicam), formulated as polymer-coated pellets. Inert seeds containing microcrystalline cellulose, lactose monohydrate, and…
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Tablet Coating Webinar by Kerry - December 17, 2020 Big pharma manufacturers are moving away from traditional in-house coating to a more efficient practice of using aqueous based ready-mix coating systems. Innovators are starting to realize that ready to use coating systems are faster, safer,…
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Pharmaceutical film coating is considered a key part in the production of solid pharmaceutical dosage forms since it gives superior organoleptic properties products. In addition, it can improve the physical and chemical stability of dosage forms, and modify the release characteristics of the drug.…
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The effectiveness of hot-melt coating depends on its uniformity and the extent to which the surface is completely covered. Compared with solvent-based coating, spreading is more limited in hot-melt coating; thus, the coating uniformity is more affected by the process parameters. This study presents…
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Here is BIOGRUNDs step-by-step guide how to prepare a suspension. Please be aware that all parameters have to be adjust individually. Equipment & Material Equipment: propeller stirrer, beaker Material: Water, AquaPolish Here is a simple calculation for a suspension with for example 20…
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Scaling up fluidised bed coating of microparticles with particle size smaller than 150 µm is a challenge because of the high tendency of particle agglomeration. Consequently, the production yield of coating trials are unsatisfactory and low spray rate is typically applied leading to long duration of…
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Pharma Excipients and BASF Pharma are presenting a live webcast together on the newly launched enteric-release coatings module of ZoomLab™. Monday, 28 September 2020 – 03:00 PM CEST Drug product development is currently based on empirical methods; the process can be time-intensive, costly, and…
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This study is based on the QbD development of extended-release (ER) extruded-spheronized pellets of Meclizine HCl and its comparative pharmacokinetic evaluation with immediate-release (IR) pellets. HPLC-fluorescence method was developed and validated for plasma drug analysis. IR drug cores were…
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