Pharma Excipients
Coating Systems and Additives
Pharmaceutical Application of Tablet Film Coating
Tablet film coating is a common but critical process providing various functionalities to tablets, thereby meeting diverse clinical needs and increasing the value of oral solid dosage forms. Tablet film coating is a technology-driven process and the evolution of coated dosage forms relies on…
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Raman Spectroscopy as a PAT-Tool for Film-Coating Processes: In-Line Predictions Using one PLS Model…
Although Raman spectroscopy has been described as a potential process analytical technique for tablet coating, it has rarely been transferred from academic studies to commercial manufacturing applications. The reasons for this are probably not only the high level of process understanding and…
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Robustness Optimization of an Existing Tablet Coating Process Applying Retrospective Knowledge…
The objective of these studies is to verify and validate the improvement in the inter-tablet coating uniformity for an industrially commercialized coated tablet, without involving changes in the approved registration dossier. Using the CPP (critical process parameters) determined from previous…
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In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it dicult to achieve therapeutic levels…
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Smart polymers for colon targeted drug delivery systems: a review
The colon targeted drug delivery has a number of important implications in the field of pharmacotherapy. Oral colon targeted drug delivery systems have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. Targeting of drugs to the…
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Mechanistic understanding of underperforming enteric coated products: Opportunities to add clinical…
Over the last 70 years several cases of in vivo failure of enteric coated (EC) formulations have been reported. The observed failures seem to be due to the slower than expected in vivo performance of EC products. Upon reaching the intestinal lumen, the dosage form is exposed to a bicarbonate…
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TABLET COATING: Discover Your Options And Avoid All Process Issues
Have you missed this webcast on tablet coating by Seppic covering the following topics?
Which coatings without TiO2?
Which coatings to optimize process time?
Which coatings to protect your tablets?
Troubleshooting: How to ensure a smooth coating?
No problem. Just get in touch with…
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Hot Melt Coating of Amorphous Carvedilol
The use of amorphous drug delivery systems is an attractive approach to improve the bioavailability of low molecular weight drug candidates that suffer from poor aqueous solubility. However, the pharmaceutical performance of many neat amorphous drugs is compromised by their tendency for…
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Quality by Design (QbD) Approach to Match Tablet Glossiness
A quality by design (QbD) approach was used for a PVA-based coating to develop a “look-alike” placebo tablet, which can match the glossiness (shine) of an innovator tablet. Critical coating parameters such as exhaust temperature, drying capacity, solid concentration in coating dispersion, and…
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Real-time monitoring of multi-layered film coating processes using Raman spectroscopy
Raman spectroscopy was used as an in-line PAT tool to predict the applied coating mass of three different coating layers on caffeine cores. The different coating suspensions contained titanium dioxide in the anatase and rutile modification and iron oxide as Raman markers.
Partial least…
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