Coating Systems and Additives

Here is BIOGRUNDs step-by-step guide how to prepare a suspension. Equipment & Material Equipment: propeller stirrer, beaker Material: Water, AquaPolish Here is a simple calculation for a suspension with for example 20 % solids content: AquaPolish® : 20 (%) 200g Water : 80 (%) 800g…
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Enteric-coated dosage forms are widely used for targeting the ileo-colonic region of the gastrointestinal (GI) tract. However, accurate targeting is challenging due to intra- and inter-individual variability in intestinal paramaters such as fluid pH and transit times which occasionally lead to…
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Why Common Approaches Are Not Effective The mechanism of action for cleaning enteric polymers is straightforward. Because enteric polymers are chemically acidic, their solubility and therefore their release is pH dependent. As a result, one would assume that they can be easily cleaned with…
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Since the Corona cases soared in February 2020, the world has come to a halt, except for the Healthcare sector, where, people are doing whatever it takes to stop the spread of this infection and cure the thousands that are infected. While the pharma industry is working day in and day out to…
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Film coating is often considered to be a challenging step in tablet manufacturing. While the choice of film coating depends on factors like API’s characteristics, protective function, release profile of a drug and aesthetics of a tablet, its important to develop a coating process which is robust and…
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You wonder how to improve tablets swallowability and taste? Look at the poster describing solutions with HPMCAS (Shin-Etsu AQOAT®) and L-HPC from their originator, Shin-Etsu. Download the Poster as a pdf here: Taste Masking Coating of Mini-Tablets with Cellulose Derivatives- Formulation and…
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The aim of this work was to develop a mathematical model to estimate the drug release from a conventional single-compartment reservoir pellet and extend its applicability to multi-compartment reservoir pellets. Conventional pellets were prepared by layering the drug onto starter-core then applying…
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Many parameters must be considered before and during the pharmaceutical coating process. Sometimes it is necessary to adjust parameters to get the best possible result. The correct and precise choice of process parameters is crucial for a flawless result and an optimal coating. Various influencing…
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The goal of the present study is to prepare a stable, multiple-unit, extended-release dosage form containing oxycodone pellets coated with aqueous ethylcellulose (EC) dispersion, Surelease E-7-19050. The application of 18% w/w of EC leads to the similar drug release with the hydrophobic,…
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Damage to the drug diffusion coat barrier of controlled release pellets by the compaction force when preparing multiple-unit pellet system tablets is a major concern. Previous studies have shown that pellets located at the tablet axial and radial peripheral surfaces were more susceptible to…
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