Pharma Excipients
Coating Systems and Additives
A novel method of quantifying the coating progress in a three-dimensional prismatic spouted bed
An optical method of experimentally quantifying the coating progress in a laboratory prismatic spouted bed is presented.
Microcrystalline cellulose particles (Cellets) with size dp = 0.57 mm are used as core material. Waterborne coating suspensions with methylene blue as a dye are used and…
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Titanium-Free Food Color Alternatives Market to Witness a Healthy Growth during 2019-2029
The growing trend for natural and organic food color is resulting in shift from titanium dioxide, a synthetic ingredient, towards titanium-free food color alternatives and extracting food colors from alternative natural sources. Natural food color sources include astaxanthin, beta carotene, annatto,…
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Comparison of the coating process and in vitro dissolution of 3 mm gastro-resistant minitablets and…
Minitablets are solid oral forms, which, due to their size (1-3 mm), may be easily swallowed by children.
The administration of minitablets in a certain number of units allows for flexible dosing for a broad age group of paediatric patients, which is particularly important for modified-release…
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Using zeta potential to study the ionisation behaviour of polymers employed in modified-release…
A range of enteric polymers is used in pharmaceutical industry for developing gastro-resistant formulations. It is generally implied that these coatings are interchangeable due to similar dissolution pH thresholds reported by suppliers.
Despite rapid dissolution in compendial phosphate buffers,…
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Effect of operation conditions on coating of pharmaceutical pellets with a film of HPMC/PEG in a…
Wurster coater was utilized for coating glass beads with HPMC/PEG. The effects of design and operating parameters on the coating process were evaluated.
It was found that the pressure drop decreases when spraying the coating solution into the bed, indicating that spraying prevents the particles…
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France to ban titanium dioxide in food from 2020 – what happens in Pharma?
France will ban Titanium dioxide as an additive in food in France from January 1, 2020, the Ministries of Ecology and Economy have said. The government has decided to ban "as a precaution" foodstuffs containing titanium dioxide (TiO2, an additive known as E171) as from 1 January 2020, the two…
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Adjustment of triple shellac coating for precise release of bioactive substances with different…
Formulations for the controlled release of substances in the human terminal ileum and colon are essential to target the gut microbiome and its interactions with the intestinal mucosa. In contrast to pharmaceutical enteric coatings, reliable food-grade alternatives are still scarce.
Shellac…
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Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: formulation, miscibility, in…
Polymeric films were prepared based on chitosan and its blends with poly(2-ethyl-2-oxazoline) by casting from aqueous solutions. These materials were characterised using a number of physicochemical techniques, including Fourier-transform infrared spectroscopy, thermal gravimetric analysis,…
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Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded…
The aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation. Therefore, a quality by design approach was implemented to model the effect of the process parameters of…
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Providing Clean Label Solutions for Vitamins & Supplements
In the global dietary supplement market, consumer demands for cleaner labels continues to drive the development of new and innovative products. Additionally, regulatory agencies are also increasingly active in ensuring the safety of food additives used in our daily lives.
As ingredients such as…
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