A wide variety of pharmaceutical products, including pellets, granules, capsules, powders, and crystals are often coated. The procedure of coating tablets is a complex process that results in the forming of a thin layer around the tablet. This layer is in the range of 20 to 200 μm in thickness, or around 1 to 9% of the initial weight of the tablet.
Pharma Excipients
Coating
Recent advances in long-acting drug delivery systems for anticancer drug
The use of systemic anticancer chemotherapy is intrinsically limited by its toxicity. Whether dealing with small molecules or biopharmaceuticals, after systemic administration, small doses fail to reach effective intratumoral concentrations, while high doses with significant tumor inhibition effects…
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Design and bioactivity of Eudragit® encapsulated pH-Sensitive enteric/gastric soluble fluorescent…
Herein, with a view to improving the poor solubility of curcumin and unfavorable optical property of pyrimidine derivatives, the two types of drugs were successfully combined through several simple reactions, and encapsulated with different types of Eudragit® (intestinal / gastric soluble and…
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A Systematic Overview of Eudragit® Based Copolymer for Smart Healthcare
Eudragit, synthesized by radical polymerization, is used for enteric coating, precise temporal release, and targeting the entire gastrointestinal system. Evonik Healthcare Germany offers different grades of Eudragit. The ratio of methacrylic acid to its methacrylate-based monomers used in the…
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Design and Optimization of a Nanoparticulate Pore Former as a Multifunctional Coating Excipient for…
Bioavailability of weakly basic drugs may be disrupted by dramatic pH changes or unexpected pH alterations in the gastrointestinal tract. Conventional organic acids or enteric coating polymers cannot address this problem adequately because they leach out or dissolve prematurely, especially during…
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Numerical Investigation of the Particle Dynamics in a Rotorgranulator Depending on the Properties of…
In the pharmaceutical industry, the coating of particles is a widely used technique to obtain desired surface modifications of the final product, e.g., controlled release of the active agents. The production of round, coated particles is particularly important, which is why fluidized bed rotor…
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Natural Biopolymers as Smart Coating Materials of Mesoporous Silica Nanoparticles for Drug Delivery
In recent years, the functionalization of mesoporous silica nanoparticles (MSNs) with different types of responsive pore gatekeepers have shown great potential for the formulation of drug delivery systems (DDS) with minimal premature leakage and site-specific controlled release. New…
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Composition-Property Relationships of pH-Responsive Poly[(2-vinylpyridine)-co-(butyl methacrylate)]…
The taste-masking of bitter-tasting active pharmaceutical ingredients is key to ensuring patient compliance when producing oral pharmaceutical formulations. This is generally achieved via the incorporation of pH-responsive, reverse enteric polymers, that prevent the dissolution of the formulation in…
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Design and Development of Fluconazole-Loaded Nanocellulose-Eudragit Vaginal Drug Delivery System
Purpose
The purpose of this research work was to evaluate the scaffolds of rice and wheat nanocellulose with Eudragit E100 for vaginal delivery of fluconazole.
Method
The nanocellulose-based scaffolds were fabricated by the lyophilization technique using a two-factor three-level central…
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Application of NMP and Neusilin US2-integrated liquisolid technique in mini-tablets for improving…
Frankincense and myrrh are widely used Chinese medicines, showing clinically relevant synergistic therapeutic effects in the treatment of inflammation and cancer. We investigated the applicability of a liquisolid (LS) technique to the preparation of mini-tablets containing supercritical fluid…
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Surface Modification of Lactose Carrier Particles Using a Fluid Bed Coater to Improve Fine Particle…
Surface roughness of carrier particles can impact dry powder inhaler (DPI) performance. There are opposing views on the effect of roughness on DPI performance. Hence, a systematic approach is needed to modify carrier surfaces and evaluate the impact on drug delivery. Carrier particle surfaces were…
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