A wide variety of pharmaceutical products, including pellets, granules, capsules, powders, and crystals are often coated. The procedure of coating tablets is a complex process that results in the forming of a thin layer around the tablet. This layer is in the range of 20 to 200 μm in thickness, or around 1 to 9% of the initial weight of the tablet.
Pharma Excipients
Coating
Quality by Design Approach for Optimization of 5-Fluorouracil Microbeads Using Box–Behnken Design…
Purpose
The main objective was to develop and optimize a multiparticulate system of 5-fluorouracil through the Box–Behnken design (BBD) and desirability function and coating of the optimized batch for increased therapeutic efficacy and targeting for the treatment of colorectal cancer.
Method
It…
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Moisture protection strategies and challenges for solid oral dosages
Protecting moisture sensitive substances from environmental moisture is one of the biggest challenges in the pharmaceutical and nutritional supplements industry. Coating the tablet core with a suitable film coating therefore plays an important role in achieving a sufficient moisture barrier. It…
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The Guide to Formulating Oral Extended-Release Tablets
Extended-release tablets, also known as sustained-release, controlled-release, or time-release tablets, have become increasingly important in the healthcare sector due to their ability to maintain consistent drug levels in the body over a specific period. This drug delivery system provides various…
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Development of Fluoride-Loaded Chitosan Microparticles for Controlled Drug Delivery: A Comparative…
Purpose
The oral administration of drugs is usually the most convenient, economical, and preferred route for patients. Chitosan is a natural polymer that is biocompatible and possesses good mucoadhesion properties and has been proposed for various biomedical applications such as scaffolds in tissue…
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MicroCoat™: A Breakthrough in Oral Multiparticulate Formulation Development
Oral multiparticulate systems are often the ‘go to’ solution for flexible dosing, especially in cases where a degree of functionality, such as taste masking or modified release, is required from the formulation. One of the preferred methods of adding functionality to multiparticulates is by fluid…
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Strategy of eudragit coated curcumin nanoparticles delivery system: Release and cell imaging studies…
Abstract
Curcumin has a broad-spectrum anti-tumor effect and has no toxic side effects. However, the unique diketone structure of curcumin will undergo diketo-enol tautomerism under different acid-base conditions, resulting in its instability under physiological conditions. In addition, the low…
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Development of a time-dependent oral colon delivery system of anaerobic Odoribacter splanchnicus for…
Odoribacter (O.) splanchnicus is an anaerobic member of the human intestinal microbiota. Its decrease in abundance has been associated with inflammatory bowel disease (IBD), non-alcoholic fatty liver, and cystic fibrosis. Considering the anti-inflammatory properties of O. splanchnicus and its…
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An evaluation of microcrystalline cellulose attributes affecting compaction-induced pellet coat…
Pellet coat damage in multi-unit pellet system (MUPS) tablets has previously been studied and addressed with limited success. The effects of lactose filler material attributes on pellet coat damage have been relatively well-studied but a similar understanding of microcrystalline cellulose (MCC) is…
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Investigation of the Kollicoat Smartseal formulation concepts on the taste masking functionality
Did you know that based on the virtual tool BitterPredict, about 40% of random molecules, 66% of clinical and experimental drugs, and almost 77% of natural products are bitter1?
This leads us to concern about the final formulation's palatability and look for alternatives to overcome the…
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Formulation development with Kollicoat Smartseal: Impact of plasticizers
How can plasticizers impact the functionality of film-coating latex-based dispersion?
When formulating a film coating, plasticizers are often required to increase polymer chain mobility, improve mechanical properties, such as elasticity and cracking resistance, and reduce the minimum film…
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