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Continuous manufacturing
Analysis of the Effects of Process Parameters on Start-Up Operation in Continuous Wet Granulation
Toward further implementation of continuous tablet manufacturing, one key issue is the time needed for start-up operation because it could lead to lower product yield and reduced economic performance. The behavior of the start-up operation is not well understood; moreover, the definition of the…
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Single-crystal Drying: Development of a Continuous Drying Prototype to Optimize Particle Flow and…
Purpose
In the pharmaceutical industry, there has been a growing interest in continuous manufacturing in recent years. Many efforts have been made to implement new process equipment for various production steps. One step which is not yet covered well is the continuous drying of the active…
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Fluidization characterization in the ConSigma 25 dryer via process data – A method of advanced…
Highlights
• Model based approach to quantify fluidization quality, exclusively using the temperature profile.
• Approach is suited for drying end-point detection in real-time due to low computational complexity.
• Systematic procedure to find suitable Granulation and drying…
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Chrono modulated multiple unit particulate systems (MUPS) via a continuous hot melt double extrusion…
The current study is aimed at the development of chrono modulated multiple unit particulate systems (MUPS) of nifedipine (ND) by a continuous double extrusion process. ND, a poorly soluble drug, was formulated into an amorphous solid dispersion (ASD) to improve its solubility. Further, the ASD was…
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Review: Continuous Manufacturing of Small Molecule Solid Oral Dosage Forms
Continuous manufacturing (CM) is defined as a process in which the input material(s) are continuously fed into and transformed, and the processed output materials are continuously removed from the system. Continuous manufacturing can be considered as matching the FDA’s so-called ‘Desired State’…
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Drying in a continuous wet granulation line: Investigation of different end of drying control…
Continuous manufacturing in the pharmaceutical industry has been gaining traction in the past few years. To fully understand and optimise continuous manufacturing processes it is important not only to focus on the single units which act as building blocks but also to understand how the parameters in…
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Galenic Lab-on-a-Chip concept for lipid nanocapsules production
The continuous production of drug delivery systems assisted by microfluidics has drawn a growing interest because of the high reproducibility, low batch-to-batch variations, narrow and controlled particle size distributions and scale-up ease induced by this kind of processes. Besides, microfluidics…
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TPLS as predictive platform for twin-screw wet granulation process and formulation development
In recent years, the interest in continuous manufacturing techniques, such as twin-screw wet granulation, has increased. However, the understanding of the influence of the combination of raw material properties and process settings upon the granule quality attributes is still limited.
In this…
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Real-time Monitoring of Powder Mass Flowrates for Plant-wide Control of a Continuous Direct…
While measurement and monitoring of powder/particulate mass flow rate are not essential to the execution of traditional batch pharmaceutical tablet manufacturing, in continuous operation, it is an important additional critical process parameter. It has a key role both in establishing that the…
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Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared…
Electrospinning is a technology for manufacture of nano- and micro-sized fibers, which can enhance the dissolution properties of poorly water-soluble drugs. Tableting of electrospun fibers have been demonstrated in several studies, however, continuous manufacturing of tablets have not been realized…
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