Browsing Category
Continuous manufacturing
Continuous Mixing Technology: Characterization of a vertical mixer using residence time distribution
Continuous powder mixing technology (CMT) application during continuous direct compression has emerged as a leading technology used in the development and manufacture of solid oral dosage forms. The critical quality attributes of the final product are heavily dependent on the performance of…
Read More...
Read More...
Impact of excipients on batch and continuous powder blending
Stimulated by Pharma 4.0, the pharmaceutical industry is changing from batch-wise to continuous manufacturing. Therefore, individual processing steps such as blending of the active pharmaceutical ingredient (API) with excipients have to be re-designed to continuous operations.
Highlights…
Read More...
Read More...
Loss-in-weight feeding, powder flow and electrostatic evaluation for direct compression…
Minimizing variability in the feeding process is important for continuous manufacturing since materials are fed individually and can impact the final product. This study demonstrates the importance of measuring powder properties and highlights the need to characterize the feeding performance both…
Read More...
Read More...
Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation…
The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely on a scientific approach to enable efficient…
Read More...
Read More...
Material tracking in a continuous direct capsule-filling process via residence time distribution…
Continuous production of pharmaceuticals requires traceability from the raw material to the final dosage form. With that regard, understanding the residence time distribution (RTD) of the whole process and its unit operations is crucial. This work describes a structured approach to characterizing…
Read More...
Read More...
Continuous blending monitored and feedback controlled by machine vision-based PAT tool
In a continuous powder blending process machine vision is utilized as a Process Analytical Technology (PAT) tool. While near-infrared (NIR) and Raman spectroscopy are reliable methods in this field, measurements become challenging when concentrations below 2 w/w% are quantified. However, an active…
Read More...
Read More...
Starch Products as Candidate Excipients in a Continuous Direct Compression Line
Direct compression (DC) remains the most preferred technique to produce tablets, and its effectiveness is directly influenced by raw material attributes. Therefore, the selection of specific grades of excipients to achieve desirable powder flow and compression properties is of importance. Shifting…
Read More...
Read More...
Implementing Feedback Granule Size Control in a Continuous Dry Granulation Line Using Controlled…
In continuous manufacturing of pharmaceuticals, dry granulation is of interest because of its large throughput capacity and energy efficiency. In order to manufacture solid oral dosage forms continuously, valid control strategies for critical quality attributes should be established. To this date,…
Read More...
Read More...
Integrated Twin-Screw Wet Granulation, Continuous Vibrational Fluid Drying and Milling: A fully…
Highly homogeneous low-dose (50 µg) tablets were produced incorporating perfectly free-flowing granules prepared by a fully integrated Continuous Manufacturing (CM) line. The adopted CM equipment consisted of a Twin-Screw Wet Granulator (TSWG), a Continuous Fluid Bed Dryer (CFBD) and a Continuous…
Read More...
Read More...
Development of integrated continuous pharmaceutical technologies
Thesis findings
1. Acetylsalicylic acid (ASA) was synthesized in continuous flow reactors for the first time. Design of experiment studies were conducted in order to optimize the two synthetic steps: i.e. the acetylation of salicylic acid (SA) and the quenching of impurities. By applying the…
Read More...
Read More...