Browsing Category
Continuous manufacturing
Hot liquid extrusion assisted drug-cyclodextrin complexation: a novel continuous manufacturing…
In this study, drug-cyclodextrin (CD) complexes were prepared using hot liquid extrusion (HLE) process with an aim to improve solubility and bioavailability of carbamazepine. Saturation solubility studies of CBZ in water and different pH media showed a pH-independent solubility. Phase solubility…
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Continuous twin screw granulation: Robustness of lactose/MCC-based formulations
In recent years, significant progress has been made in the field of continuous twin screw granulation. However, only limited knowledge is currently available on the impact of active pharmaceutical ingredient (API) properties on granule quality and processability. In this study, the response behavior…
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Tablet Quality-Prediction Model Using Quality Material Attributes: Toward Flexible Switching Between…
Purpose
The purpose of the study was to develop a model to predict the critical quality attribute (CQA) of tablets during continuous and batch manufacturing using only critical material attributes (CMAs).
Methods
Experiments were performed using ethenzamide as the active pharmaceutical…
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Customized continuous solutions for oral solid dosage forms
With the technology platform MODCOS you can run several OSD processes: from powder to tablet, from powder to straw, from powder to stickpack, from powder to sachet, from powder to dry suspension and from powder to capsule. One solution for all - a quick overview in the video:
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5 solutions to common formulation challenges
1. Trouble finding a soluble DC filler/binder with pleasant taste and mouthfeel for non-GMO, lactose free formulations?
TRY EMDEX® - REQUEST A SAMPLE
EMDEX® is a directly compressible, water-soluble tablet binder and filler. Its unique composition of 95% glucose monohydrate and different…
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continuous twin screw granulation and fluid bed drying: a mechanistic scaling approach focusing…
This study provides the results of investigation on scaling approaches for three differently-sized continuous granulation lines, each consisting of a twin screw wet granulation process and a continuous fluid bed drying process. To check the initial scaling approach with regard to granule and tablet…
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Deep learning for continuous manufacturing of pharmaceutical solid dosage form
Continuous Manufacturing (CM) of pharmaceutical drug products is a new approach within the pharmaceutical industry. In the presented paper, a GMP continuous wet granulation line for production of solid dosage forms was investigated. The line was composed of the subsequent continuous unit: operations…
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From powder to tablets: Investigation of residence time distributions in a continuous manufacturing…
The essence of Continuous Manufacturing (CM) resides in the fact that continuous process units are directly connected to each other forming a continuous process train. The thorough understanding of material flow in this train based on suitable sensors, including on-line process analytical…
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Converting a batch based high-shear granulation process to a continuous dry granulation process
When one wishes to convert a batch based manufacturing process of an existing tablet product to a continuous process, there are several available strategies which can be adopted. Theoretically, the most straightforward way would be to proceed with the corresponding processing principles, for example…
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In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet…
Wetting is the initial stage of wet granulation processes during which the first contact between the powder and the liquid occurs. Wetting is a critical step to allow granule growth and consolidation, but also to ensure uniform active pharmaceutical ingredient (API) distribution over all granule…
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