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Continuous manufacturing
Continuous twin screw granulation: Influence of process and formulation variables on granule quality…
In recent years, continuous manufacturing techniques, such as twin screw wet granulation, have gained significant momentum.
Due to the large diversity of the (model) formulations and equipment, it is often difficult to generalize conclusions about the importance of process settings. As only…
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Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying
Continuous manufacturing (CM) is a promising strategy to achieve various benefits in the context of quality, flexibility, safety and cost in pharmaceutical production.
One of the main technical challenges of CM is that the process needs to handle transient conditions such as the start-up phase…
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Mapping key process parameters to the performance of a continuous dry powder blender in a continuous…
This work aims to expand the typical raw material attributes that can successfully be processed on a continuous direct compression line with a particular focus on the continuous dry powder blender. Three grades of Acetaminophen were investigated as model active pharmaceutical ingredients and chosen…
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Continuous manufacturing process monitoring of pharmaceutical solid dosage form: A case study
Continuous Manufacturing (CM) of pharmaceutical drug products is a rather new approach within the pharmaceutical industry. In the presented paper, a GMP continuous wet granulation line used for clinical production of solid dosage forms was investigated with a thorough monitoring strategy regarding…
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A novel approach to support formulation design on twin screw wet granulation technology:…
The overall objective of this work is to understand how excipient characteristics influence the drug product quality attributes and process performance of a continuous twin screw wet granulation process. The knowledge gained in this study is intended to be used for Quality by Design (QbD)-based…
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