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Continuous manufacturing
Can Continuous Manufacturing of Topical Semisolids by Hot Melt Extrusion Soon Be a Reality?
For more than five decades, pharmaceutical manufacturers have been relying heavily on batch manufacturing that is a sequential, multistep, laborious, and time-consuming process. However, late advances in manufacturing technologies have prompted manufacturers to consider continuous manufacturing (CM)…
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Comparison of Ceolus™ Grades in Continuous Manufacturing (Wet Granulation) – Continuous…
1. Introduction
Until now, batch manufacturing has been the main mode of pharmaceutical manufacture: raw materials are input and processed in a stage of the process then removed for input and process in the next stage of the sequence. However, in recent years, manufacturers have explored…
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Integrated continuous melt granulation-based powder-to-tablet line: process investigation and…
In the last decades, continuous manufacturing (CM) has become a research priority in the pharmaceutical industry. However, significantly fewer scientific researches address the investigation of integrated, continuous systems, a field that needs further exploration to facilitate the implementation of…
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Regulatory Considerations for Excipients used in Lipid Nanoparticles
Lipid excipients and delivery systems such as lipid nanoparticles (LNPs) are essential for a wide variety of therapeutics including chemotherapy, analgesics, gene therapy, respiratory and ocular applications, anti-fungal applications, and vaccines (see Figure 2).1 In many cases, these excipients…
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On the Influence of Raw Material Attributes on Process Behaviour and Product Quality in a Continuous…
Continuous manufacturing of oral solids is a complex process in which critical material attributes (CMAs), formulation and critical process parameters (CPPs) play a fundamental role. However, assessing their effect on the intermediate and final product’s critical quality attributes (CQAs) remains…
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Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance
Abstract
The pharmaceutical industry is undergoing a paradigm shift towards continuous processing from batch, where continuous direct compression (CDC) is considered to offer the most straightforward implementation amongst powder processes due to the relatively low number of unit operations or…
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Comparison of Ceolus™ Grades – Continuous Manufacturing System “Granuformer® Gf-2050”
Comparison of Ceolus™ Grades in Continuous Manufacturing (Wet Granulation) - Continuous Manufacturing System “Granuformer® Gf-2050”
Introduction
Until now, batch manufacturing has been the main mode of pharmaceutical manufacture: raw materials are input and processed in a stage of the process then…
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Comparison of Ceolus™ Grades in Continuous Manufacturing of Tablets using Direct Compression
1. Introduction
The introduction of continuous manufacturing of tablets has been gaining momentum, because it offers reductions in development and manufacturing costs and time and improved reliability of quality assurance.
In this study, grades of Ceolus™, microcrystalline cellulose (MCC) in…
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Hot-melt extruded in situ gelling systems (MeltDrops Technology): Formulation development, in silico…
In situ gelling systems (ISGS) can prolong retention time and bioavailability of ophthalmic solutions. The complexity and cost of ISGS avert their industrial scale-up and clinical implementation. In this study, we demonstrate novel application of hot-melt extrusion (HME) technology for continuous…
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Control oriented modeling of twin-screw granulation in the ConsiGma-25 production plant
ConsiGmaTM-25 is a continuous production plant integrating a twin-screw granulation, fluid bed drying, granule conditioning, and a tableting unit. The particle size distribution (PSD), active pharmaceutical ingredient (API) content, and liquid content of wet granules after twin-screw granulation…
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