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Crospovidone
Disintegration property of ODTs with co-processed excipients – Application note
Performance of orally disintegrating tablets (ODTs) with GRANFILLER-D was investigated by the real-time X-ray observation of water penetration into ODTs.
Orally disintegrating tablets (ODTs) have gotten attention as they improve medication adherence for patients who have issues in swallowing,…
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Effect of the molecular mobility of water adsorbed by disintegrants on storage-induced hydrolytic…
The purpose of this study was to investigate the effect of molecular mobility of water adsorbed by disintegrants on the hydrolytic degradation of active pharmaceutical ingredients (APIs). Fourteen different disintegrants were tested. First, powdered disintegrants were stored at conditions of 40…
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Design and evaluation of bioenhanced oral tablets of Dunaliella salina microalgae for treatment of…
The application of Dunaliella salina (D. salina) microalgae in nutraceutical products is limited due to poor aqueous solubility and consequently low bioavailability of the existing β-carotene. The aim of the present study is the design of bioenhanced oral tablets of D. salina powder prepared by…
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Contrasting the crospovidones functionality as excipients for direct compression
14 March 2016
Specific values of technological properties of excipients allow the establishment of numerical parameters to de ne and compare their functionality. This study investigates the functionality of Polyplasdones XL and XL10. Parameters studied included tablet disintegration…
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STEP Database Updated – 40 Excipients now!
25. February 2016
The STEP stands for Safety and Toxicity of Excipients for Paediatrics. It is a user-designed resource developed by European Paediatric Formulation Initiative (EuPFI) and United States Paediatric Formulation Initiative (USPFI) in collaboration for storage and…
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Development of novel multifunction directly compressible co-processed excipient by melt granulation…
27. October 2015
Introduction:
The objective of the present investigation was to develop a novel multifunctional directly compressible co-processed excipient consisting of dibasic calcium phosphate anhydrous, polyethylene glycol 4000 (PEG 4000) and crospovidone using Box-Behnken design.…
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A Quality by Experimental Design Approach to Assess the Effect of Formulation and Process Variables…
22. July 2015
Successful pellet production has been reported in literature with cross-linked poly(vinylpyrrolidone), Polyplasdone® XL-10 and INF-10. In the present study, a quality by experimental design approach was used to assess several formulation and process parameter effects…
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