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Crospovidone
Modelling the Compaction Step of a Platform Direct Compression Process
The ability to predict formulation behaviour at production scale during formulation design can reduce the time to market and decrease product development costs. However, it is challenging to extrapolate compaction settings for direct compression formulations between tablet press models during…
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Process Model Approach to Predict Tablet Weight Variability for Direct Compression Formulations at…
Optimizing processing conditions to achieve a critical quality attribute (CQA) is an integral part of pharmaceutical quality by design (QbD). It identifies combinations of material and processing parameters ensuring that processing conditions achieve a targeted CQA. Optimum processing conditions are…
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Technical insight into potential functional-related characteristics (FRCs) of sodium starch…
Functional-related characteristics (FRCs) are properties of excipients that can potentially influence one or more functions of that excipient in the final product. Knowledge of FRCs is important for formulation development and also to assess the risks of excipient variability on final product…
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Pharmaceutical Development of Film-Coated Mini-Tablets with Losartan Potassium for Epidermolysis…
Epidermolysis bullosa is a genetically heterogenous skin fragility disorder with multiorgan involvement appearing already in newborn children. Severe progressive fibrosis follows skin blistering, mucosa lesions, and wound healing, favouring development of highly aggressive squamous cell carcinomas.…
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Concept of Orodispersible or Mucoadhesive “Tandem Films” and Their Pharmaceutical Realization
Orodispersible or mucoadhesive films as a patient-oriented dosage form for low-dosed drugs are usually produced using solvent casting. This paper presents a modification of the solvent casting technique that aimed to divide oral films into two or more compartments.
The proposed objectives and…
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Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible…
Development of orodispersible minitablets (ODMTs) requires consideration of aspects related to small dimensions, while ensuring short disintegration time with sufficient mechanical stability. In order to meet these and other critical quality attributes (CQAs), quality by design is encouraged.…
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GRANFILLER-D™ Water Absorption Behavior and Disintegration Mechanism
In the formulation design of conventional orally disintegrating tablets (ODTs) by direct compression, disintegratablity often reduces when active pharmaceutical ingredient (API) content is high. Since API tends to block the gap between particles in tablets, which is considered to be the main water…
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Influence of commonly used excipients on the chemical degradation of enalapril maleate in its solid…
The physicochemical stability of enalapril maleate was investigated in the presence of fourteen different excipients divided into four different classes. The extent of a drug-excipient interaction was investigated by following the chemical stability using HPLC. It was found that there is a certain…
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Investigating the Role of Excipients on the Physical Stability of Directly Compressed Tablets
Stability studies are an integral part of the drug development process for any drug product. In addition to monitoring chemical degradation, the physical stability of a drug product must also be evaluated to ensure that the drug release and performance is not affected by storage. In this study,…
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Understanding the Effect of Energy Density and Formulation Factors on the Printability and…
Selective laser sintering (SLS) is a rapid prototyping technique for the production of three-dimensional objects through selectively sintering powder-based layer materials. The aim of the study was to investigate the effect of energy density (ED) and formulation factors on the printability and…
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