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Crospovidone
Formulation and Evaluation of Baclofen-Meloxicam Orally Disintegrating Tablets (ODTs) Using…
Purpose: This study aimed to formulate an orally disintegrating tablet (ODT) containing both baclofen and meloxicam together for treating osteoarthritis.
Methods: Direct compression method was used to prepare ODTs using three types of co-processed excipients (Prosolv ODT G2®, F-melt®, and…
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Statistical design of experiment-based formulation development and optimization of 3D printed oral…
Purpose
Producing several controlled- release 3D printed tablets from polymer blends with the required target product profile has been a challenge. Thus, experimental design could be applied to rationally explore the impact of the formulation excipients on drug release.
Methods
The optimization…
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Time-controlled release by the incorporation of superdisintegrants within the coat of zein dry…
The aim of this work was to develop zein-based press coated tablets for delayed, time-controlled drug release. Press coated tablets containing dextrates and chlorpheniramine maleate (BCS class 1 drug) in the core, and zein and either NaCl, sodium starch glycolate (SSG) or crospovidone (XPVP) in the…
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An ultrasonographic assisted investigation for the enhancement of duodenal/cecal motility of…
Gastrointestinal (GI) disorders affect millions of people and are considered a major cause of global morbidity. Mosapride citrate (MOS) is a prokinetic agent with antiemetic effect. The drug suffers from poor bioavailability that is induced by its low solubility. The present study aimed to enhance…
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Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of…
The current study evaluated the effect of location and amount of various superdisintegrants on the properties of tablets made by twin-screw melt granulation (TSMG). Sodium-croscarmellose (CCS), crospovidone (CPV), and sodium starch glycolate (SSG) were used in various proportions intra- and…
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Manufacturability and Properties of Granules and Tablets Using the Eco-Friendly Granulation Method…
This study aimed to compare the manufacturability and granule and tablet properties of green fluidized bed granulation (GFBG) and of direct compression (DC). Acetaminophen was used as a low compactabil- ity model drug. The process time of GFBG to produce final mixtures was comparable to that of DC,…
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Formulation of sublingual promethazine hydrochloride tablets for rapid relief of motion sickness
The delivery of antihistaminic agents via the oral route is problematic, especially for elderly patients. This study aimed to develop a sublingual formulation of promethazine hydrochloride by direct compression, and to mask its intensely bitter taste. Promethazine hydrochloride (PMZ) sublingual…
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Alginates as tablet disintegrants: Understanding disintegration mechanisms and defining ranges of…
Alginates are biopolymers that have been investigated for their use in food and medical fields. Minimal information is available regarding their potential application as tablet superdisintegrants. Here we studied the disintegration action of sodium alginate (SA), calcium alginate (CA) and alginic…
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Design, Development, and Evaluation of Controlled Release Tablets of Nateglinide Solid Dispersions
The current study deals with formulation and evaluation of nateglinide solid dispersion (SD) incorporate into tablet formulation for controlled release of the drug.
Methods: The nateglinide SD prepared using crospovidone and evaluated for drug content and drug dissolution. The optimized…
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Impact of co-processed excipient particles solidity and circularity on critical quality attributes…
The selection of appropriate functional co-processed excipient (CPE) is a crucial stage in orodispersible minitablets (ODMTs) development. This paper aimed to identify the most important morphological attributes influencing the flowability and homogeneity of powder mixtures and minitablets final…
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