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Cyclodextrin
A review on the latest developments of mesoporous silica nanoparticles as a promising platform for…
Cancer is the second cause of human mortality after cardiovascular disease around the globe. Conventional cancer therapies are chemotherapy, radiation, and surgery. In fact, due to the lack of absolute specificity and high drug concentrations, early recognition and treatment of cancer with…
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Eudragit® L100/Polyvinyl Alcohol Nanoparticles Impregnated Mucoadhesive Films as Ocular Inserts for…
The fast elimination of drugs from the cornea is one of many challenges associated with the topical administration of conventional dosage forms. The present manuscript aimed to prepare modified-release inserts containing erythromycin (ERY) to enhance drug delivery and address the aforementioned…
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Dextrin-Based Nanohydrogels for Rokitamycin Prolonged Topical Delivery
Macrolides are widely used antibiotics with a broad spectrum of activity. The development of drug carriers to deliver this type of antibiotics has attracted much research. The present study aims at developing new swellable dextrin-based nanohydrogels for the topical delivery of rokitamycin, as model…
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Cyclodextrin superstructures for drug delivery
Cyclodextrins, typically known for their molecular encapsulation properties to form inclusion complexes with guests of adequate size and hydrophobicity, have recently been explored in tridimensional supramolecular assemblies. These structures have additional advantages over inclusion complexes: they…
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Cyclodextrin-based delivery systems in parenteral formulations: a critical update review
Parenteral formulations are indispensable in clinical practice and often are the only option to administer drugs that cannot be administrated through other routes, such as proteins and certain anticancer drugs - which are indispensable to treat some of the most prevailing chronic diseases worldwide…
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Spray-Dried and Spray-Freeze-Dried Powder Formulations of an Anti-Interleukin-4Rα Antibody for…
Objective
The therapeutic options for severe asthma are limited, and the biological therapies are all parenterally administered. The purpose of this study was to formulate a monoclonal antibody that targets the receptor for IL-4, an interleukin implicated in the pathogenesis of severe asthma, into…
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Preparation and Characterization of Clopidogrel Bisulfate-Hydroxypropyl-β-Cyclodextrin Mixed…
The study aimed to increase the intestinal solubility and absorption of orally bioavailable clopidogrel-bisulfate (CPB) by complexing with hydroxypropyl-β-cyclodextrin (HCD) to form a binary inclusion complex that was stabilized by Tween 80 (T80) resulting into mixed inclusion complex. The results…
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Enhanced Oral Bioavailability of MT-102, a New Anti-inflammatory Agent, via a Ternary Solid…
This study aimed to develop a solid dispersion (SD) of MT-102, a new anti-inflammatory agent, to improve its oral bioavailability. The ternary SD formulations of MT-102 (a poorly soluble extract of Isatis indigotica and Juglans mandshurica) were prepared using a solvent evaporation method with…
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Inhaled Therapy for COVID-19: Considerations of Drugs, Formulations and Devices
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for the COVID-19 pandemic, has outspread at full tilt across the world. Although several effective vaccines continue to be deployed, reliable antiviral treatments have yet to be developed against this…
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Superporous poly(β-Cyclodextrin) cryogels as promising materials for simultaneous delivery of both…
Here, one step, simple preparation of superporous p(β-cyclodextrin) (p(β-CD)) cryogels in the presence of various ratios of crosslinker, divinyl sulfone (DVS) e.g., 100, 150, 200% mole with respect to the mole ratio of 6 hydroxyl groups on β-CD unit under cryogenic conditions were reported for the…
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