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Cyclodextrin
Role of Cyclodextrins and Drug Solid State Properties on Flufenamic Acid Dissolution Performance…
Flufenamic acid (FFA) is a non-steroidal anti-inflammatory drug characterised by a low solubility and problems of variable dissolution rate and bio-inequivalence. Different FFA batches, obtained by different suppliers, showed different powder characteristics (particle size, shape and surface…
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Lipid Nanoparticles for the Posterior Eye Segment
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior…
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Effect of Soluplus® on γ-cyclodextrin solubilization of irbesartan and candesartan and their…
The poor aqueous solubility of irbesartan (IRB) and candesartan cilexetil (CAC) may hamper their bioavailability when orally or topically administered. Among several attempts, the promising nanoaggregate formation by γ-cyclodextrin (γCD) complexation of drugs in aqueous solution with or without…
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Transformation of nanoparticles into compacts: A study on PLGA and celecoxib nanoparticles
Oral delivery of nanoparticles possesses many advantages for delivery of active pharmaceutical ingredients (APIs) to the gastrointestinal tract. However, the poor physical stability of nanoparticles in liquid state is often a challenge. Removing water from the nanosuspensions and transforming the…
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Chitosan/cyclodextrin surface-adsorbed naringenin-loaded nanocapsules enhance bacterial quorum…
Pathogenic bacteria use quorum sensing (QS), a cell-to-cell communication process that uses small signalling molecules, to regulate several essential virulence factors such as bioluminescence, biofilm formation, and bacterial motility. Naringenin, a bitter and colourless flavanone ubiquitous in…
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Food-grade olive oil Pickering emulsions stabilized by starch/β-cyclodextrin complex nanoparticles:…
The beneficial effects of olive oil consumption make it be one of the leading healthy edible oils worldwide. However, the water insolubility and oxidation of olive oil hinder its applications. In this study, food-grade oil-in-water olive oil Pickering emulsions (OOPEs) stabilized by hybrid…
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Development of fast-dissolving dosage forms of curcuminoids by electrospinning for potential tumor…
Curcuminoids (CUs) of antitumor and various other potential biological activities have extremely low water solubility therefore special formulation was elaborated. New fast dissolving reconstitution dosage forms of four CUs were prepared as fibrous form of 2-hydroxypropyl-β-cyclodextin (HP-β-CD). In…
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Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing Polygoni…
Polygoni cuspidati root is a resveratrol-rich source with anti-inflammatory, angiogenic and neuroprotective effects. The raw material was standardized for the content of resveratrol, for which there is a special justification for administration within the oral mucosa. To improve the solubility of…
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Combined Use of Cyclodextrins and Amino Acids for the Development of Cefixime Oral Solutions for…
Cefixime (CEF) is a cephalosporin included in the WHO Model List of Essential Medicines for Children. Liquid formulations are considered the best choice for pediatric use, due to their great ease of administration and dose-adaptability. Owing to its very low aqueous solubility and poor stability,…
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How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium…
The aim of our study was to explore the potential value of metallic (Ag, Cu, and Zn) salts, polymer/metallic nanoparticles, and chlorhexidine (CHX) for improving the antimicrobial activity of calcium hydroxide (CH) against E. faecalis and C. albicans, associated with persistent endodontic…
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