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Cyclodextrin
pH/H2O2 Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active…
Nano-drug delivery systems (nano-DDSs) with an existing specific interaction to tumor cells and intelligent stimulus-triggered drug delivery performance in a tumor microenvironment (TME) remain hotspots for effective cancer therapy. Herein, multifunctional pH/H2O2 dual-responsive chiral mesoporous…
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Encapsulation of Phenolic Compounds from a Grape Cane Pilot-Plant Extract in Hydroxypropyl…
Grape canes, the main byproducts of the viticulture industry, contain high-value bioactive phenolic compounds, whose application is limited by their instability and poorly solubility in water. Encapsulation in cyclodextrins allows these drawbacks to be overcome. In this work, a grape cane…
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New potential application of hydroxypropyl-β-cyclodextrin in solid self-nanoemulsifying drug…
The purpose of this study was to use hydroxypropyl-β-cyclodextrin (HP-β-CD) as a novel carrier in solid SNEDDS and solid dispersions to enhance the solubility and oral bioavailability of poorly water-soluble dexibuprofen. The novel dexibuprofen-loaded solid SNEDDS was composed of dexibuprofen,…
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Tetrahydrocurcumin encapsulation in cyclodextrins for water solubility improvement: synthesis,…
The solubility of the scarcely water-soluble molecule tetrahydrocurcumin (THC), a promising curcumin derivative to be used as biopesticide, was enhanced through the formation of inclusion complexes with different cyclodextrins (CDs). Randomly methylated β-cyclodextrin (MeβCD) gave the best results…
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Formulation of Chewable Tablets Containing Carbamazepine-β-cyclodextrin Inclusion Complex and F-Melt…
Due to its low solubility, carbamazepine (CBZ) exhibits slow and incomplete release in the gastrointestinal tract and, hence, variable pharmacokinetics and pharmacodynamic effect. Lots of methods have been devised to improve its solubility, the large number of proposed solutions being a sign that…
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Microfibrous cyclodextrin boosts flame retardancy of poly(lactic acid)
2-hydroxypropyl-β-cyclodextrin (HP-β-CD) microfibres with diameters ranging between 3-7 µm were prepared by aqueous solution based high-speed electrospinning (HSES) technique and then used as carbonising agent at 3 wt% loading besides 15 wt% ammonium polyphosphate (APP) to obtain…
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The bitterness masking effect of β-cyclodextrin in the formulation of ODTs using Granfiller D
CycloLab Cyclodextrin R&D Laboratory, Ltd., Hungary and Daicel Corporation have jointly published a white paper on the bitterness masking effect of β-cyclodextrin (β-CD) in the formulation of orally disintegrating tablets (ODTs) using GRANFILLER-D.
ODTs disintegrate in the oral cavity within…
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The Effect of Drug Loading on the Properties of Abiraterone–Hydroxypropyl Beta Cyclodextrin Solid…
Abiraterone is a poorly water-soluble drug used in the treatment of prostate cancer. In our previous study, we reported that KinetiSol® processed solid dispersions (KSDs) based on hydroxypropyl β-cyclodextrin (HPBCD) showed improved dissolution and pharmacokinetics of abiraterone. However, the…
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Preparation and evaluation of vancomycin spray dried powders for pulmonary delivery
The aim of the current study was to achieve a dry powder formulation of vancomycin by spray drying whilst evaluating the effect of pH and excipient type and percentage used in formulation on particle characteristics and aerosolization performance. A D-optimal design was applied to optimize the…
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Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and…
Veklury™ by Gilead Sciences, Inc., containing antiviral drug, remdesivir (REM) has received emergency authorization in the USA and in Europe for COVID-19 therapy. Here, for the first time, we describe details of the non-covalent, host-guest type interaction between REM and the solubilizing…
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