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Cyclodextrin
Characterization of Sulfobutyl Ether Betacyclodextrin Binary and Ternary Inclusion Complexes of…
Background: Poor solubility and dissolution of drugs are major hindering factors in the development of their
oral dosage forms with acceptable bioavailability. Of the various approaches, employing amorphous form of
drugs is frequently utilized to develop drug products. Inclusion complexation is…
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Enhancement of solubility and dissolution rate of fenofibrate using β-Cyclodextrin
The aim of the present research work, fenofibrate a BCS class II antihyperlipidemic drug belongs to fibrate class was formulated as solid dispersions using various hydrophilic carriers to enhance the solubility, dissolution rate, and oral bioavailability.
Methodology: Various techniques such as…
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Fabrication and evaluation of fast disintegrating pellets of cilostazol
The present study was designed to formulate and develop fast disintegrating pellets of poorly soluble model drug (cilostazol) by reducing the proportion of micro-crystalline cellulose with pre-gelatinized starch (PGS), lactose and chitosan. The bioavailability enhancement of a model drug was…
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Role of the Encapsulation in Bioavailability of Phenolic Compounds
Plant-derived phenolic compounds have multiple positive health effects for humans attributed to their antioxidative, anti-inflammatory, and antitumor properties, etc. These effects strongly depend on their bioavailability in the organism. Bioaccessibility, and consequently bioavailability of…
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Design and formulation of polymeric nanosponge tablets with enhanced solubility for combination…
Three drugs namely caffeine, paracetamol, and aceclofenac are commonly used for treating various acute and chronic pain related ailments. These 3 drugs have varied solubility profiles, and formulating them into a single tablet did not have the desired dissolution profile for drug absorption. The…
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Hot liquid extrusion assisted drug-cyclodextrin complexation: a novel continuous manufacturing…
In this study, drug-cyclodextrin (CD) complexes were prepared using hot liquid extrusion (HLE) process with an aim to improve solubility and bioavailability of carbamazepine. Saturation solubility studies of CBZ in water and different pH media showed a pH-independent solubility. Phase solubility…
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β-cyclodextrin polymer/Soluplus® encapsulated Ebselen ternary complex (EβpolySol) as a potential…
Highlights
• β-cyclodextrin polymer showed 3–4 folds higher saturation solubility of Ebselen.
• β-cyclodextrin polymer was safer on HeLa cells compared to monomeric cyclodextrin.
• EβpolySol film rapidly disintegrated and immediately released EB in vaginal fluid.
• EβpolySol film…
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Enhanced Loading Efficiency and Mucoadhesion Properties of Gellan Gum Thin Films by Complexation…
Polymeric oral thin films (OTFs) were prepared by the casting method, combining gellan gum (GG), a water-soluble polysaccharide, and glycerol (Gly) as a plasticizing agent. GG-Gly films were investigated as potential systems for buccal drug delivery using fluconazole (Class I of the…
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Remdesivir: First Approval
The antiviral agent remdesivir (Veklury®; Gilead Sciences), nucleotide analogue prodrug, has broad-spectrum activity against viruses from several families. Having demonstrated potent antiviral activity against coronaviruses in preclinical studies, remdesivir emerged as a candidate drug for the…
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Cannabidiol aqueous solubility enhancement: Comparison of three amorphous formulations strategies…
Poor aqueous solubility of terpenophenolic compound Cannabidiol (CBD) is a major issue in the widespread use of this promising therapeutic polyphenol. Moreover, choosing the appropriate strategy to overcome this challenge is time-consuming and based on trial–error processes. The amorphous form of…
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