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Cyclodextrin
Preparation and in vitro characterization of rosuvastatin calcium incorporated methyl beta…
Despite being the most effective hypolipidemic agent, poor physicochemical properties of Rosuvastatin calcium (RCa) remain challenging obstacles in the development of pharmaceutical dosage forms. Inclusion complexes (ICs) of RCa with cyclodextrin (CD) derivatives; methyl-beta-cyclodextrin (M-β-CD)…
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Electrospun Solid Formulation of Anaerobic Gut Microbiome Bacteria
A model anaerobic bacterium strain from the gut microbiome (Clostridium butyricum) producing anti-inflammatory molecules was incorporated into polymer-free fibers of a water-soluble cyclodextrin matrix (HP-β-CD) using a promising scaled-up nanotechnology, high-speed electrospinning. A long-term…
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Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin…
A new cyclodextrin polypseudorotaxanes nail lacquer (Regenail®) containing biotin, methyl sulphonyl methane (MSM), and dimethylsilanediol salicylate was developed and evaluated in vitro and in vivo. The product was developed to improve nail status and diminish signs of pathological nail alterations.…
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New Research Reveals a Promising Functional Alternative to Surfactants within Biologic Formulations
One of the most common challenges when formulating biological molecules for therapeutic use is overcoming the molecules’ tendency to aggregate. Currently, the nonionic surfactants polysorbate 80 and polysorbate 20 are widely used to stabilize proteins in liquid preparations for parenteral…
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Progress in the design and development of “fast-dissolving” electrospun nanofibers based drug…
Electrospinning has emerged as most viable approach for the fabrication of nanofibers with several beneficial features that are essential to various applications ranging from environment to biomedicine. The electrospun nanofiber based drug delivery systems have shown tremendous advancements over the…
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Development of a stable oral pediatric solution of hydrochlorothiazide by the combined use of…
Hydrochlorothiazide (HCT) is widely used in pediatrics for hypertension management. Due to the lack of pediatric commercial forms, community or hospital pharmacies generally prepare HCT extemporaneous pediatric suspensions by dispersing in water a portion of a crushed tablet or the drug powder;…
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Immobilization of β-CD on a Hyper-Crosslinked Polymer for the Enhanced Removal of Amines from…
In this paper, we adopted a simple and efficient strategy to prepare a β-cyclodextrin (β-CD)-modified hyper-crosslinked polymer (CDM-HCP). The structures and physicochemical properties of the as-synthesized polymer were also evaluated. It was applied to the removal of anilines from aqueous…
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In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it dicult to achieve therapeutic levels…
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Tackling Coronavirus: The role of Roquette’s KLEPTOSE® HPβCD in the fight against COVID-19 –…
Hydroxypropyl β-cyclodextrin (HPβCD) has been shown to be effective as solubilizing and stabilizing agents in vaccines, monoclonal antibodies, and oral formulations.
Watch our expert video, featuring Pharma and BioPharma Scientists – Dr. Foo Wen Chin and Dr. Peng Tao – who explain how Roquette’s…
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Computer-Aided Discovery of New Solubility-Enhancing Drug Delivery System
The poor aqueous solubility of active pharmaceutical ingredients (APIs) places a limit on their therapeutic potential. Cyclodextrins (CDs) have been shown to improve the solubility of APIs, but the magnitude of the improvement depends on the structure of both the CDs and APIs. We have developed…
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