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Cyclodextrin
Combating Coronavirus: Key Role of Cyclodextrins in Treatment and Prevention
A new strain of coronavirus (2019-nCoV) started to emerge in late December 2019 from Wuhan, the capital of Hubei Province in central China, which is a city with a population of 11 million. The pneumonia- like illness, which has spread rapidly since first appearing in late December 2019, was declared…
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Microwave-assisted β-cyclodextrin/chrysin inclusion complexation: An economical and green strategy…
Highlights
• 1:1 solid inclusion complex (IC) of chrysin with β-cyclodextrin prepared.
• Microwave irradiation method is time-saving and environmentally benign.
• Microwaved IC has highest drug content, solubility and hemocompatibility.
• Microwaved IC displayed superior…
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Factors affecting the stability and performance of amorphous solid dispersions of poorly soluble…
Over the last twenty years, the poor solubility profile of pipeline drugs has limited their development as solid oral dosage forms. Formulating these APIs as amorphous solid dispersions is one strategy to overcome their poor aqueous solubility. The major limitation to amorphous solid dispersion…
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Oral tablet formulations containing cyclodextrin complexes of poorly water soluble cefdinir to…
Cefdinir (CFD) is an oral cephalosporin antibiotic commonly used in the treatment of community-acquired infections. The oral bioavailability of CFD is limited due to its poor aqueous solubility. Cyclodextrins (CyDs) and their chemically modified derivatives are used in the pharmaceutical field to…
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Mechanochemical activation with cyclodextrins followed by compaction as an effective approach to…
Rutin is one of the most important flavonoids with poor bioavailability. This work aimed at addressing the issue of poor biopharmaceutical performance of rutin by applying a combination of complexation with secondary processing into tablets. Mechanical activation was the most suitable method of…
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Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical…
Acyclovir (ACV) is one of the most used antiviral drugs for the treatment of herpes simplex virus infections and other relevant mucosal infections caused by viruses. Nevertheless, the low water solubility of ACV limits both its bioavailability and antiviral performance. The combination of block…
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Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics
Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs.
The CDs can…
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The role of Roquette’s KLEPTOSE® HPβCD in the fight against coronavirus
Geneva, IL (USA), February 11, 2020 – Roquette has recently identified that its KLEPTOSE® hydroxypropyl beta-cyclodextrins (HPβCD) product, a functional excipient and a specialty active pharmaceutical ingredient (API), may be effective to help the joint efforts of the scientific and pharmaceutical…
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Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron
The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug‐cyclodextrin complexes and then combined with the filler mannitol.
Two…
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Semisolid-filled Capsules of Carvedilol for Improving Dissolution Behaviour
The present investigation was aimed at enhancing the dissolution properties of carvedilol, a poorly water-soluble drug using a combination of solid dispersion and semisolid-filled capsule. The use of lauroyl polyoxyl-6 glycerides as a carrier in a semisolid base to improve the dissolution behaviour…
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