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Cyclodextrin
Olanzapine, improvement of biopharmaceutical performance in solid dosage form
Olanzapine is an effective antipsychotic drug used for the treatment of positive and negative symptoms of schizophrenia.
It suffers from poor water solubility in addition to extensive first-pass metabolism in the liver to inactive metabolites, resulting in a poor oral bioavailability of nearly…
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Orodispersible Carbamazepine/Hydroxypropyl-β-Cyclodextrin Tablets Obtained by Direct Compression…
The development of orodispersible tablets (ODTs) for poorly soluble and poorly flowable drugs via direct compression is still a challenge.
This work aimed to develop ODTs of poorly soluble drugs by combining cyclodextrins that form inclusion complexes to improve wetting and release properties,…
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Cyclodextrin polymer improves atherosclerosis therapy and reduces ototoxicity
Recently, cyclodextrin (CD) has shown the potential for effective treatment of atherosclerotic plaques in mice by solubilizing plaque cholesterol.
While promising as a new therapy for atherosclerosis, poor pharmacokinetics and ototoxicity of CD pose a therapeutic challenge. Thus far, however,…
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Cyclodextrins: Emerging Medicines of the New Millennium
Cyclodextrins, since their discovery in the late 19th century, were mainly regarded as excipients. Nevertheless, developments in cyclodextrin research have shown that some of these hosts can capture and include biomolecules, highlighting fatty acids and cholesterol, which implies that they are not…
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Species differences in ocular pharmacokinetics and pharmacological activities of regorafenib and…
Age-related macular degeneration (AMD) is the leading cause of severe vision impairment in patients over the age of 60 years.
Choroidal neovascularization (CNV) is the hallmark of neovascular AMD and vascular endothelial growth factor (VEGF) plays a causal role in the formation of CNV. Although…
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Cyclodextrins in Drug Delivery Systems and their Effects on Biological Barriers
Cyclodextrins are widely used excipients, composed of glucopyranose units with a cyclic structure. One of their most important properties, is that their inner cavity is hydrophobic, while their surface is hydrophilic. This enables them for the complex formation with lipophilic molecules. They have…
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Controlled Delivery of Dutasteride Using Dissolvable Microarrays: Initial Formulation and In-vivo…
Dutasteride is prescribed as a once daily oral capsule for the treatment of symptomatic benign prostatic hyperplasia.
As an alternative and patient focused drug product, this laboratory evaluated the potential to deliver dutasteride in a controlled/sustained manner when formulated as a…
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Insights of Taste Masking from Molecular Interactions and Microstructures of Microspheres
The effects of taste masking are determined by interactions between drug and excipients as well as the microstructures of the particulate drug delivery systems (DDS).
Cyclodextrin (CD) is a widely used taste masking agent, to which the relationship between kinetic parameters (Ka and Kd) of a drug…
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Improved oral bioavailability of anticancer drug tamoxifen through complexation with water soluble…
Tamoxifen (TMX), a class II antiestrogen drug consistent with the biopharmaceutical classification system, shows low plasma levels leading to therapeutic failure as a result of poor aqueous solubility.
Complexation with multifunctional excipients cyclodextrins (CDs) is an effective technique to…
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Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications
Electrospun nanofibers have sparked tremendous attention in drug delivery since they can
offer high specific surface area, tailored release of drugs, controlled surface chemistry for preferred
protein adsorption, and tunable porosity. Several functional motifs were incorporated into electrospun…
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