Pharma Excipients
DC excipient
PEARLITOL® 200 GT Mannitol by Roquette
Speed. Precision. Patient-centricity.
Roquette´s PEARLITOL® 200 GT granulated mannitol is here to revolutionize direct compression. Realize the potential of novel drug formats with smaller, harder tablets produced at unprecedented speeds – without compromising on quality.
PEARLITOL® 200 GT…
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Formulation development and optimization of prasugrel final dosage form by direct compression method
Abstract
Background:
Prasugrel is a member of thienopyridine class of ADP receptors that reduce the aggregation ("Clumping") of platelets by irreversibly binding to P2Y12 receptors.
Objective:
The aim of this study is to develop new formulation of Prasugrel tablets by direct compression…
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PEARLITOL® CR-H by Roquette
SEE PEARLITOL® CR-H
Roquette´s new, industry-first mannitol and hydroxypropyl methylcellulose (HPMC) blend, designed for controlled release drug formulation. Leave behind wet granulation, lengthy drying times and limited flowability and unlock the potential of direct compression to create…
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Oligonucleotide Formulations Prepared by High-Speed Electrospinning: Maximizing Loading and…
The aim of this study was to develop antisense oligonucleotide tablet formulations using high-speed electrospinning. Hydroxypropyl-beta-cyclodextrin (HPβCD) was used as a stabilizer and as an electrospinning matrix. In order to optimize the morphology of the fibers, electrospinning of various…
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Predicting pharmaceutical powder flow from microscopy images using deep learning
The powder flowability of active pharmaceutical ingredients and excipients is a key parameter in the manufacturing of solid dosage forms used to inform the choice of tabletting methods. Direct compression is the favoured tabletting method; however, it is only suitable for materials that do not show…
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Formulation of taste-masked orodispersible famotidine tablets by sequential spray drying and direct…
Since famotidine (FA) is prescribed for gastrointestinal diseases orodispersible tablets could contribute to patients’ compliance. Its bitter taste and poor compressibility pose formulation challenges which were addressed in this study. Famotidine/mannitol (FA/MA) binary solution was spray dried…
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Design and Evaluation of Sustained Release Bilayer Tablets of Oxcarbazepine
Objective
The aim of the present study is to modify the release profile of oxcarbazepine by formulating it as a bilayer tablet using direct compression method with dual compression.
Methods
In the bilayer system, the immediate release layer was formulated using four types of disintegrants, sodium…
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Enhanced blend uniformity and flowability of low drug loaded fine API blends via dry coating: The…
Although previous research demonstrated improved flowability, packing, fluidization, etc. of individual powders via nanoparticle dry coating, none considered its impact on very low drug loaded blends. Here, fine ibuprofen at 1, 3, and 5 wt% drug loadings (DL) was used in multi-component blends to…
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Behaviour of magnesium stearate at particle–particle interfaces: Microdynamic flowability to monitor…
Monitoring magnesium stearate (MgSt) surface coverage remains a challenge in powders. Microdynamic flowability is proposed to better understand the nature of these films and how formulation and process variability affect the final product. The method examined small-scale particulate solids in motion…
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CEOLUS – High compactible Microcrystalline Cellulose
Are you experiencing capping issues? Are you facing edge chipping? Compactability challenge?
We offer a problem solver! - CEOLUS™ MCC
CEOLUS™KG – High compactible Microcrystalline Cellulose
Benefits
Faciliate high dosage formulation
Lower tablet friability
Realize low pressure…
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