Pharma Excipients
DC excipient
Exploiting synergistic effects of brittle and plastic excipients in directly compressible…
Direct compression (DC) is the simplest and most economical way to produce pharmaceutical tablets. Ideally, it consists of only two steps: dry blending of a drug substance(s) with excipients followed by compressing the powder mixture into tablets. In this study, immediate-release film-coated tablets…
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The Use of Sodium Alginate in Extended Release Tablet Formulations
Extended release tablets are commonly based on partially synthetic cellulose ethers, such as hypromellose (HPMC), hydroxyethyl cellulose (HEC), or hydroxypropyl cellulose (HPC). Alginates offer an interesting, all-natural alternative to these polymers. The aim of the present study was to…
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Downstream Processing of Amorphous and Co-Amorphous Olanzapine Powder Blends
The work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The flowability and the compressibility of amorphous and co-amorphous OLZ with saccharin (SAC) and the properties of the tablets obtained were measured and compared to those…
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Development and Use of a Residence Time Distribution (RTD) Model Control Strategy for a Continuous…
Residence-time-distribution (RTD)-based models are key to understanding the mixing dynamics of continuous manufacturing systems. Such models can allow for material traceability throughout the process and can provide the ability for removal of non-conforming material from the finished product. These…
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Application of different models to evaluate the key factors of fluidized bed layering granulation…
Different modeling approaches were used to understand the key factors affecting the outcomes of pulse sprayed FBLG. A large amount of metformin hydrochloride (~83%) was layered onto Cellets® seeds to obtain directly compressible granules. The effect of spray rate, mass flow rate, inlet air…
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Why not choose DC co-processed excipients in your ODT formulation?
Direct compression (DC) is the simplest process to manufacture tablets. The advantage of DC is that the simplicity of the manufacturing process can reduce manufacturing costs and manufacturing time. On the other hand, we often encounter challenges, such as tableting trouble, tablet weight…
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Impact of alternative lubricants on process and tablet quality for direct compression
Internal lubrication with magnesium stearate (MgSt) is associated with a reduced tensile strength and prolonged disintegration and dissolution times. In the current study, alternative lubricants to MgSt were compared with regard to lubrication efficacy and their impact on tablet properties. The…
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Roquette Expands PEARLITOL® SD Mannitol Range for Highly Sensitive Active Pharmaceutical…
Roquette, a global leader in plant-based ingredients and a leading provider of pharmaceutical excipients, today announces the addition of a new grade to its PEARLITOL® SD mannitol range for direct compression – PEARLITOL® 150 SD. Developed specifically for active pharmaceutical ingredients (APIs)…
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A multivariate formulation and process development platform for direct compression
The efficient development of robust tableting processes is challenging due to the lack of mechanistic understanding on the impact of raw material properties and process parameters on tablet quality. The experimental determination of the effect of process and formulation parameters on tablet…
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Particle Agglomeration of Acid-Modified Tapioca Starches: Characterization and Use as Direct…
Acid-modified tapioca starches (AMTSs) possessed good compressibility but showed poor particle flowability for preparing tablets by the direct compression method. The aims of this work were to prepare and characterize AMTS agglomerates using polyvinylpyrrolidone (PVP) as an agglomerating agent. The…
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