Pharma Excipients
DC excipient
Material optimization for the development of delayed release formulation using computational tools
The present study involves designing a delayed-release tablet formulation of a drug belonging to BCS class-III further chemically classified as bisphosphonate to improve bioavailability. The typical approach to drug design experimentation calls for only one variable to be altered at a time, with all…
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The Performance of PROSOLV® EASYtab SP in Four Medium-Dose, Direct Compression Formulations with…
In the present study, the performance of PROSOLV® EASYt ab SP was tested in four DC formulations with different model APIs. Each of the selected APIs presented a particular challenge in terms of producing tablets with suitable hardness, weight uniformity, content uniformity and/or reliable…
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Development and Optimization of Microballoons Assisted Floating Tablets of Baclofen
The objective of the present study was to develop microballoons aided gastro-retentive floating tablets of baclofen, a skeletal muscle relaxant with a low elimination half-life of ~ 3.5 h. Baclofen floating tablet was prepared to offer convenience by designing a tablet that would float in the…
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Comparing Environmental Impacts of Direct Compaction versus Wet Granulation Tableting Methods for…
Pharmaceutical tablet productions by direct compaction (DC) are more environmentally sustainable than wet granulation (WG) owed to DC’s lower energy consumption. For drug particles with poor flowability, however, the environmental benefits of DC become questionable because DC of such drugs requires…
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Formulation, Optimization and Evaluation of Ticagrelor Loaded Self Microemulsifying Chewable Tablets
Ticagrelor is a new generation Adenosine diphosphate receptor inhibitor drug which is highly lipohilic having poor aqueous solubility used in the treatment of Acute Coronary Syndrome and prevention of Thrombotic events like Stroke and Heart Attack. An approach has been made to develop Chewable…
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Directly compressible formulation of immediate release rosuvastatin calcium tablets stabilized with…
Reliable and stable tablet formulations for rosuvastatin calcium in four strengths: 5 mg, 10 mg, 20 mg and 40 mg have been developed. Rosuvastatin is a cholesterol-lowering statin drug and is known to be unstable during storage. The possibility of its stabilization with inorganic salts of…
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Development, In-Vitro and Ex-Vivo Evaluation of Muco-Adhesive Buccal Tablets Of Hydralazine…
Hydralazine hydrochloride is an anti-hypertensive drug. The drug has poor oral bioavailability (BA) of about 30- 50% due to extensive first-pass metabolism. Hence, the buccal delivery was used to enhance the BA of hydralazine hydrochloride. Buccal muco-adhesive tablets were prepared by direct…
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Influence of rheological behavior of lactose powders on the weight consistency of tablets –…
The 12th APV PBP World Meeting took place from 28 – 31 March 2022 in Rotterdam. There was a poster section at the event where really interesting scientific posters were presented. Therefore we asked the presenting scientists if we could share their work in addition online with the Pharma Excipients…
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Pharmatrans SANAQ® DC customized solutions for DiCOM SANAQ® direct compression applications
Pharmatrans SANAQ® offers a wide range of tailored and customized excipients for solid dosage forms tailored for direct compression (DiCOM) manufacturing processes.
These solutions help overcome a series of industry challenges, such as production difficulties, supply problems, and manufacturing…
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A Quality by Design (QbD) study in direct compression using the most flowable microcrystalline…
OBJECTIVE
CEOLUSTM UF-702 is the most flowable microcrystalline cellulose (MCC). While UF-702 has higher compactibility than standard grade PH-102, it has the lowest repose angle of known commercial grades of MCC. This is because the UF-702 particle has a round shape and has many pores inside its…
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