Pharma Excipients
DC excipient
Role of Cyclodextrins and Drug Solid State Properties on Flufenamic Acid Dissolution Performance…
Flufenamic acid (FFA) is a non-steroidal anti-inflammatory drug characterised by a low solubility and problems of variable dissolution rate and bio-inequivalence. Different FFA batches, obtained by different suppliers, showed different powder characteristics (particle size, shape and surface…
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Impact of Vertical Blender Unit Parameters on Subsequent Process Parameters and Tablet Properties in…
The continuous manufacturing of solid oral-dosage forms represents an emerging technology among the pharmaceutical industry, where several process steps are combined in one production line. As all mixture components, including the lubricant (magnesium stearate), are passing simultaneously through…
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Design-of-experiment approach to quantify the effect of nano-sized silica on tableting properties of…
There are challenges to implementing high-speed direct compression tableting for poor flow, low-density cohesive powder. Thus, excipients with adequate flowability and bulk density are desired to facilitate this process. As a major novelty, the effect of nano-sized silica (Aerosil 200®) on the…
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GRANFILLER-D™ Water Absorption Behavior and Disintegration Mechanism
In the formulation design of conventional orally disintegrating tablets (ODTs) by direct compression, disintegratablity often reduces when active pharmaceutical ingredient (API) content is high. Since API tends to block the gap between particles in tablets, which is considered to be the main water…
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100% visual inspection of tablets produced with continuous direct compression and coating
Visual appearance of tablets is an important property for patients. Since the visual appearance is most strongly influenced by the applied coating, this necessitates a high level of process control and homogeneity in the coating process. In recent years, a number of tablet coaters have been…
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Real-Time Monitoring of Powder Mass Flowrates for Plant-Wide Control of a Continuous Direct…
While measurement and monitoring of powder/particulate mass flow rate are not essential to the execution of traditional batch pharmaceutical tablet manufacturing, in continuous operation, it is an important additional critical process parameter. It has a key role both in establishing that the…
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Streamlining tablet lubrication design via model-based design of experiments
In oral solid dosage production through direct compression powder lubrication must be carefully selected to facilitate the manufacturing of tablets without degrading product manufacturability and quality (e.g. dissolution). To do so, several semi-empirical models relating compression performance to…
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Continuous direct compression: Development of an empirical predictive model and challenges regarding…
In this study, an empirical predictive model was developed based on the quantitative relationships between blend properties, critical quality attributes (CQA) and critical process parameters (CPP) related to blending and tableting. The blend uniformity and API concentration in the tablets were used…
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Optimization of diluents on the basis of SeDeM-ODT expert system for formulation development of ODTs…
The present study aimed to optimize diluents characteristics (rheological characteristics, compressibility and disintegration behavior) using SeDeM-ODT expert system, to mask poor characteristics of APIs and will help in development of a formulation which is to be processed by direct compression…
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Investigating the Role of Excipients on the Physical Stability of Directly Compressed Tablets
Stability studies are an integral part of the drug development process for any drug product. In addition to monitoring chemical degradation, the physical stability of a drug product must also be evaluated to ensure that the drug release and performance is not affected by storage. In this study,…
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